In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model

Scott M. Herting; Yonghong Ding; Anthony J. Boyle; Daying Dai; Landon D. Nash; Solmaz Asnafi; Daniel R. Jakaitis; Collin R. Johnson; Lance M. Graul; Chung Yeh; David F. Kallmes; Ramanathan Kadirvel; Duncan J. Maitland

doi:10.1002/jbm.b.34337

In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model

Scott M. Herting, Yonghong Ding, Anthony J. Boyle, Daying Dai, Landon D. Nash, Solmaz Asnafi, Daniel R. Jakaitis, Collin R. Johnson, Lance M. Graul, Chung Yeh, David F. Kallmes, Ramanathan Kadirvel, Duncan J. Maitland

Radiology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Shape memory polymer (SMP) foam-coated coils (FCCs) are new embolic coils coated with porous SMP designed to expand for increased volume filling and enhanced healing after implantation. The purpose of this study was to compare chronic aneurysm healing after treatment with SMP FCCs to bare platinum coil (BPC) controls in the rabbit elastase aneurysm model. BPCs or SMP FCCs were implanted in rabbit elastase-induced aneurysms for follow-up at 30 days (n = 10), 90 days (n = 5), and 180 days (n = 12 for BPCs; n = 14 for SMP FCCs). Aneurysm occlusion and histologic healing, including a qualitative healing score, neointima thickness, collagen deposition, and inflammation were compared between the two groups. The mean neointima thickness was significantly greater in groups treated with SMP FCCs for all three time points. Histologic healing scores and collagen deposition quantification suggested that aneurysms treated with SMP FCCs experience more complete healing of the dome by 90 days, but the differences were not statistically significant. More progressive occlusion and recanalization were observed in aneurysms treated with SMP FCCs, but neither difference was statistically significant. Additionally, the SMP foam used in the FCCs was found to degrade faster in the rabbit elastase model than expected based on previous studies in a porcine sidewall aneurysm model. This study suggests that SMP FCCs can promote neointima formation along the aneurysm neck, and may lead to more complete healing of the dome and neck. These findings indicate potential benefits of this device for aneurysm occlusion procedures.

Original language	English (US)
Pages (from-to)	2466-2475
Number of pages	10
Journal	Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume	107
Issue number	8
DOIs	https://doi.org/10.1002/jbm.b.34337
State	Published - Nov 1 2019

Keywords

aneurysm healing
embolization device
polyurethane foam
shape memory polymer

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

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10.1002/jbm.b.34337

Cite this

Herting, S. M., Ding, Y., Boyle, A. J., Dai, D., Nash, L. D., Asnafi, S., Jakaitis, D. R., Johnson, C. R., Graul, L. M., Yeh, C., Kallmes, D. F., Kadirvel, R., & Maitland, D. J. (2019). In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 107(8), 2466-2475. https://doi.org/10.1002/jbm.b.34337

In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model. / Herting, Scott M.; Ding, Yonghong; Boyle, Anthony J. et al.
In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 107, No. 8, 01.11.2019, p. 2466-2475.

Research output: Contribution to journal › Article › peer-review

Herting, SM, Ding, Y, Boyle, AJ, Dai, D, Nash, LD, Asnafi, S, Jakaitis, DR, Johnson, CR, Graul, LM, Yeh, C, Kallmes, DF , Kadirvel, R & Maitland, DJ 2019, 'In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model', Journal of Biomedical Materials Research - Part B Applied Biomaterials, vol. 107, no. 8, pp. 2466-2475. https://doi.org/10.1002/jbm.b.34337

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title = "In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model",

abstract = "Shape memory polymer (SMP) foam-coated coils (FCCs) are new embolic coils coated with porous SMP designed to expand for increased volume filling and enhanced healing after implantation. The purpose of this study was to compare chronic aneurysm healing after treatment with SMP FCCs to bare platinum coil (BPC) controls in the rabbit elastase aneurysm model. BPCs or SMP FCCs were implanted in rabbit elastase-induced aneurysms for follow-up at 30 days (n = 10), 90 days (n = 5), and 180 days (n = 12 for BPCs; n = 14 for SMP FCCs). Aneurysm occlusion and histologic healing, including a qualitative healing score, neointima thickness, collagen deposition, and inflammation were compared between the two groups. The mean neointima thickness was significantly greater in groups treated with SMP FCCs for all three time points. Histologic healing scores and collagen deposition quantification suggested that aneurysms treated with SMP FCCs experience more complete healing of the dome by 90 days, but the differences were not statistically significant. More progressive occlusion and recanalization were observed in aneurysms treated with SMP FCCs, but neither difference was statistically significant. Additionally, the SMP foam used in the FCCs was found to degrade faster in the rabbit elastase model than expected based on previous studies in a porcine sidewall aneurysm model. This study suggests that SMP FCCs can promote neointima formation along the aneurysm neck, and may lead to more complete healing of the dome and neck. These findings indicate potential benefits of this device for aneurysm occlusion procedures.",

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author = "Herting, {Scott M.} and Yonghong Ding and Boyle, {Anthony J.} and Daying Dai and Nash, {Landon D.} and Solmaz Asnafi and Jakaitis, {Daniel R.} and Johnson, {Collin R.} and Graul, {Lance M.} and Chung Yeh and Kallmes, {David F.} and Ramanathan Kadirvel and Maitland, {Duncan J.}",

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AU - Herting, Scott M.

AU - Ding, Yonghong

AU - Boyle, Anthony J.

AU - Dai, Daying

AU - Nash, Landon D.

AU - Asnafi, Solmaz

AU - Jakaitis, Daniel R.

AU - Johnson, Collin R.

AU - Graul, Lance M.

AU - Yeh, Chung

AU - Kallmes, David F.

AU - Kadirvel, Ramanathan

AU - Maitland, Duncan J.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Shape memory polymer (SMP) foam-coated coils (FCCs) are new embolic coils coated with porous SMP designed to expand for increased volume filling and enhanced healing after implantation. The purpose of this study was to compare chronic aneurysm healing after treatment with SMP FCCs to bare platinum coil (BPC) controls in the rabbit elastase aneurysm model. BPCs or SMP FCCs were implanted in rabbit elastase-induced aneurysms for follow-up at 30 days (n = 10), 90 days (n = 5), and 180 days (n = 12 for BPCs; n = 14 for SMP FCCs). Aneurysm occlusion and histologic healing, including a qualitative healing score, neointima thickness, collagen deposition, and inflammation were compared between the two groups. The mean neointima thickness was significantly greater in groups treated with SMP FCCs for all three time points. Histologic healing scores and collagen deposition quantification suggested that aneurysms treated with SMP FCCs experience more complete healing of the dome by 90 days, but the differences were not statistically significant. More progressive occlusion and recanalization were observed in aneurysms treated with SMP FCCs, but neither difference was statistically significant. Additionally, the SMP foam used in the FCCs was found to degrade faster in the rabbit elastase model than expected based on previous studies in a porcine sidewall aneurysm model. This study suggests that SMP FCCs can promote neointima formation along the aneurysm neck, and may lead to more complete healing of the dome and neck. These findings indicate potential benefits of this device for aneurysm occlusion procedures.

AB - Shape memory polymer (SMP) foam-coated coils (FCCs) are new embolic coils coated with porous SMP designed to expand for increased volume filling and enhanced healing after implantation. The purpose of this study was to compare chronic aneurysm healing after treatment with SMP FCCs to bare platinum coil (BPC) controls in the rabbit elastase aneurysm model. BPCs or SMP FCCs were implanted in rabbit elastase-induced aneurysms for follow-up at 30 days (n = 10), 90 days (n = 5), and 180 days (n = 12 for BPCs; n = 14 for SMP FCCs). Aneurysm occlusion and histologic healing, including a qualitative healing score, neointima thickness, collagen deposition, and inflammation were compared between the two groups. The mean neointima thickness was significantly greater in groups treated with SMP FCCs for all three time points. Histologic healing scores and collagen deposition quantification suggested that aneurysms treated with SMP FCCs experience more complete healing of the dome by 90 days, but the differences were not statistically significant. More progressive occlusion and recanalization were observed in aneurysms treated with SMP FCCs, but neither difference was statistically significant. Additionally, the SMP foam used in the FCCs was found to degrade faster in the rabbit elastase model than expected based on previous studies in a porcine sidewall aneurysm model. This study suggests that SMP FCCs can promote neointima formation along the aneurysm neck, and may lead to more complete healing of the dome and neck. These findings indicate potential benefits of this device for aneurysm occlusion procedures.

KW - aneurysm healing

KW - embolization device

KW - polyurethane foam

KW - shape memory polymer

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In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model

Abstract

Keywords

ASJC Scopus subject areas

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