Abstract
Comprehensive in vivo biodegradability and biocompatibility of unmodified and Arg-Gly-Asp (RGD) peptidemodified PEG/sebacic acid-based hydrogels were evaluated and compared to the control material poly(lactide-co-glycolide) (PLGA) using a cage implantation system, as well as direct subcutaneous implantation for up to 12 weeks. The total weight loss after 12 weeks of implantation for unmodified PEGSDA and RGD-modified PEGSDA in the cage was ∼42% and 52%, respectively, with no statistical difference (p > 0.05). The exudate analysis showed that PEGSDA hydrogels induced minimal inflammatory response up to 21 days following implantation, similar to the controls (empty cage and the cage containing PLGA discs). Histology analysis from direct subcutaneous implantation of the hydrogels and PLGA scaffold showed statistically similar resolution of the acute and chronic inflammatory responses with development of the fibrous capsule between the PEGSDA hydrogels and the control (PLGA). The cage system, as well as the histology analysis, demonstrated that the degradation products of both hydrogels, with or without RGD peptide modification, are biocompatible without statistically significant differences in the inflammatory responses, as compared to PLGA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 191-197 |
| Number of pages | 7 |
| Journal | Journal of Biomedical Materials Research - Part A |
| Volume | 95 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 2010 |
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Keywords
- Cage implantation
- Hydrogel
- In vivo biocompatibility
- In vivo biodegradation
- PEG sebacic acid diacrylate (PEGSDA)
- RGD-modified hydrogel
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
- Ceramics and Composites
- Metals and Alloys
- Medicine(all)
Cite this
In vivo biodegradation and biocompatibility of PEG/sebacic acid-based hydrogels using a cage implant system. / Kim, Jinku; Dadsetan, Mahrokh; Ameenuddin, Syed; Windebank, Anthony John; Yaszemski, Michael J; Lu, Lichun.
In: Journal of Biomedical Materials Research - Part A, Vol. 95, No. 1, 10.2010, p. 191-197.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo biodegradation and biocompatibility of PEG/sebacic acid-based hydrogels using a cage implant system
AU - Kim, Jinku
AU - Dadsetan, Mahrokh
AU - Ameenuddin, Syed
AU - Windebank, Anthony John
AU - Yaszemski, Michael J
AU - Lu, Lichun
PY - 2010/10
Y1 - 2010/10
N2 - Comprehensive in vivo biodegradability and biocompatibility of unmodified and Arg-Gly-Asp (RGD) peptidemodified PEG/sebacic acid-based hydrogels were evaluated and compared to the control material poly(lactide-co-glycolide) (PLGA) using a cage implantation system, as well as direct subcutaneous implantation for up to 12 weeks. The total weight loss after 12 weeks of implantation for unmodified PEGSDA and RGD-modified PEGSDA in the cage was ∼42% and 52%, respectively, with no statistical difference (p > 0.05). The exudate analysis showed that PEGSDA hydrogels induced minimal inflammatory response up to 21 days following implantation, similar to the controls (empty cage and the cage containing PLGA discs). Histology analysis from direct subcutaneous implantation of the hydrogels and PLGA scaffold showed statistically similar resolution of the acute and chronic inflammatory responses with development of the fibrous capsule between the PEGSDA hydrogels and the control (PLGA). The cage system, as well as the histology analysis, demonstrated that the degradation products of both hydrogels, with or without RGD peptide modification, are biocompatible without statistically significant differences in the inflammatory responses, as compared to PLGA.
AB - Comprehensive in vivo biodegradability and biocompatibility of unmodified and Arg-Gly-Asp (RGD) peptidemodified PEG/sebacic acid-based hydrogels were evaluated and compared to the control material poly(lactide-co-glycolide) (PLGA) using a cage implantation system, as well as direct subcutaneous implantation for up to 12 weeks. The total weight loss after 12 weeks of implantation for unmodified PEGSDA and RGD-modified PEGSDA in the cage was ∼42% and 52%, respectively, with no statistical difference (p > 0.05). The exudate analysis showed that PEGSDA hydrogels induced minimal inflammatory response up to 21 days following implantation, similar to the controls (empty cage and the cage containing PLGA discs). Histology analysis from direct subcutaneous implantation of the hydrogels and PLGA scaffold showed statistically similar resolution of the acute and chronic inflammatory responses with development of the fibrous capsule between the PEGSDA hydrogels and the control (PLGA). The cage system, as well as the histology analysis, demonstrated that the degradation products of both hydrogels, with or without RGD peptide modification, are biocompatible without statistically significant differences in the inflammatory responses, as compared to PLGA.
KW - Cage implantation
KW - Hydrogel
KW - In vivo biocompatibility
KW - In vivo biodegradation
KW - PEG sebacic acid diacrylate (PEGSDA)
KW - RGD-modified hydrogel
UR - http://www.scopus.com/inward/record.url?scp=77956476202&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956476202&partnerID=8YFLogxK
U2 - 10.1002/jbm.a.32810
DO - 10.1002/jbm.a.32810
M3 - Article
C2 - 20574982
AN - SCOPUS:77956476202
VL - 95
SP - 191
EP - 197
JO - Journal of Biomedical Materials Research - Part A
JF - Journal of Biomedical Materials Research - Part A
SN - 1549-3296
IS - 1
ER -