In vivo biodegradation and biocompatibility of PEG/sebacic acid-based hydrogels using a cage implant system

Jinku Kim, Mahrokh Dadsetan, Syed Ameenuddin, Anthony John Windebank, Michael J Yaszemski, Lichun Lu

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Comprehensive in vivo biodegradability and biocompatibility of unmodified and Arg-Gly-Asp (RGD) peptidemodified PEG/sebacic acid-based hydrogels were evaluated and compared to the control material poly(lactide-co-glycolide) (PLGA) using a cage implantation system, as well as direct subcutaneous implantation for up to 12 weeks. The total weight loss after 12 weeks of implantation for unmodified PEGSDA and RGD-modified PEGSDA in the cage was ∼42% and 52%, respectively, with no statistical difference (p > 0.05). The exudate analysis showed that PEGSDA hydrogels induced minimal inflammatory response up to 21 days following implantation, similar to the controls (empty cage and the cage containing PLGA discs). Histology analysis from direct subcutaneous implantation of the hydrogels and PLGA scaffold showed statistically similar resolution of the acute and chronic inflammatory responses with development of the fibrous capsule between the PEGSDA hydrogels and the control (PLGA). The cage system, as well as the histology analysis, demonstrated that the degradation products of both hydrogels, with or without RGD peptide modification, are biocompatible without statistically significant differences in the inflammatory responses, as compared to PLGA.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalJournal of Biomedical Materials Research - Part A
Volume95
Issue number1
DOIs
StatePublished - Oct 2010

Fingerprint

Hydrogels
Biodegradation
Biocompatibility
Polyethylene glycols
Acids
Histology
Polyglactin 910
Biodegradability
Exudates and Transudates
Scaffolds
Peptides
Capsules
Weight Loss
sebacic acid
polylactic acid-polyglycolic acid copolymer
Degradation

Keywords

  • Cage implantation
  • Hydrogel
  • In vivo biocompatibility
  • In vivo biodegradation
  • PEG sebacic acid diacrylate (PEGSDA)
  • RGD-modified hydrogel

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys
  • Medicine(all)

Cite this

In vivo biodegradation and biocompatibility of PEG/sebacic acid-based hydrogels using a cage implant system. / Kim, Jinku; Dadsetan, Mahrokh; Ameenuddin, Syed; Windebank, Anthony John; Yaszemski, Michael J; Lu, Lichun.

In: Journal of Biomedical Materials Research - Part A, Vol. 95, No. 1, 10.2010, p. 191-197.

Research output: Contribution to journalArticle

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