In vivo assessment of renal tissue viscoelasticity during acute and gradual renal ischemia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Elasticity imaging methods have been used to study kidney mechanical properties and have demonstrated that kidney elasticity changes with disease state. Moreover, recent studies have demonstrated that kidney elasticity is affected by renal blood flow. The purpose of this study is to evaluate the feasibility of Shearwave Dispersion Ultrasound Vibrometry (SDUV) for in vivo measurements of viscoelasticity in healthy swine kidney and to demonstrate that kidney viscoelasticity is affected by renal blood flow. A total of five female pigs were used in these acute in vivo experiments. Shear wave speed dispersion was studied by exciting shear waves in the renal cortex with a mechanical actuator and with acoustic radiation force. Kidney viscoelasticity was studied at baseline renal blood flow (RBF) and 25, 50, 75 and 100% of baseline RBF. In this study we show that shear wave speed is affected by RBF. As a consequence, shear elastic moduli is affected by RBF. The data from this study did not show a clear relation between viscosity and renal blood flow. Moreover, the data from this study indicates that other variables such as local blood flow, pressure, and volume as well as method accuracy need to be measured to illustrate the relationship between shear elasticity and viscosity with acute and chronic kidney processes.

Original languageEnglish (US)
Title of host publication2011 IEEE International Ultrasonics Symposium, IUS 2011
Pages2102-2105
Number of pages4
DOIs
StatePublished - Dec 1 2011
Event2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States
Duration: Oct 18 2011Oct 21 2011

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2011 IEEE International Ultrasonics Symposium, IUS 2011
CountryUnited States
CityOrlando, FL
Period10/18/1110/21/11

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Keywords

  • Renal elasticity
  • Renal viscosity
  • Shear wave dispersion

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Amador, C., Urban, M. W., Chen, S., & Greenleaf, J. F. (2011). In vivo assessment of renal tissue viscoelasticity during acute and gradual renal ischemia. In 2011 IEEE International Ultrasonics Symposium, IUS 2011 (pp. 2102-2105). [6293249] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2011.0521