TY - GEN
T1 - In vivo assessment of renal tissue viscoelasticity during acute and gradual renal ischemia
AU - Amador, Carolina
AU - Urban, Matthew W.
AU - Chen, Shigao
AU - Greenleaf, James F.
PY - 2011
Y1 - 2011
N2 - Elasticity imaging methods have been used to study kidney mechanical properties and have demonstrated that kidney elasticity changes with disease state. Moreover, recent studies have demonstrated that kidney elasticity is affected by renal blood flow. The purpose of this study is to evaluate the feasibility of Shearwave Dispersion Ultrasound Vibrometry (SDUV) for in vivo measurements of viscoelasticity in healthy swine kidney and to demonstrate that kidney viscoelasticity is affected by renal blood flow. A total of five female pigs were used in these acute in vivo experiments. Shear wave speed dispersion was studied by exciting shear waves in the renal cortex with a mechanical actuator and with acoustic radiation force. Kidney viscoelasticity was studied at baseline renal blood flow (RBF) and 25, 50, 75 and 100% of baseline RBF. In this study we show that shear wave speed is affected by RBF. As a consequence, shear elastic moduli is affected by RBF. The data from this study did not show a clear relation between viscosity and renal blood flow. Moreover, the data from this study indicates that other variables such as local blood flow, pressure, and volume as well as method accuracy need to be measured to illustrate the relationship between shear elasticity and viscosity with acute and chronic kidney processes.
AB - Elasticity imaging methods have been used to study kidney mechanical properties and have demonstrated that kidney elasticity changes with disease state. Moreover, recent studies have demonstrated that kidney elasticity is affected by renal blood flow. The purpose of this study is to evaluate the feasibility of Shearwave Dispersion Ultrasound Vibrometry (SDUV) for in vivo measurements of viscoelasticity in healthy swine kidney and to demonstrate that kidney viscoelasticity is affected by renal blood flow. A total of five female pigs were used in these acute in vivo experiments. Shear wave speed dispersion was studied by exciting shear waves in the renal cortex with a mechanical actuator and with acoustic radiation force. Kidney viscoelasticity was studied at baseline renal blood flow (RBF) and 25, 50, 75 and 100% of baseline RBF. In this study we show that shear wave speed is affected by RBF. As a consequence, shear elastic moduli is affected by RBF. The data from this study did not show a clear relation between viscosity and renal blood flow. Moreover, the data from this study indicates that other variables such as local blood flow, pressure, and volume as well as method accuracy need to be measured to illustrate the relationship between shear elasticity and viscosity with acute and chronic kidney processes.
KW - Renal elasticity
KW - Renal viscosity
KW - Shear wave dispersion
UR - http://www.scopus.com/inward/record.url?scp=84869078158&partnerID=8YFLogxK
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U2 - 10.1109/ULTSYM.2011.0521
DO - 10.1109/ULTSYM.2011.0521
M3 - Conference contribution
AN - SCOPUS:84869078158
SN - 9781457712531
T3 - IEEE International Ultrasonics Symposium, IUS
SP - 2102
EP - 2105
BT - 2011 IEEE International Ultrasonics Symposium, IUS 2011
T2 - 2011 IEEE International Ultrasonics Symposium, IUS 2011
Y2 - 18 October 2011 through 21 October 2011
ER -