In vivo assessment of calcium alginate gel for endovascular embolization of a cerebral arteriovenous malformation model using the swine rete mirabile

Timothy A. Becker, Daryl R. Kipke, Mark C. Preul, William D. Bichard, Cameron G. McDougall, Bernard Bendok, Elad I. Levy, Lee R. Guterman, L. Nelson Hopkins, Perry P. Ng, Randall T. Higashida, Robert H. Rosenwasser, Robert A. Solomon

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

OBJECTIVE: We sought to assess the stability of calcium alginate as an embolic agent in an animal model of a cerebral arteriovenous malformation (AVM). Swine cerebral AVM models were used to test the injectability, radiographic visualization, mechanical stability, and biocompatibility of calcium alginate as an occlusive agent. METHODS: The swine cerebral AVM model included a carotid-to-jugular anastomosis to increase flow to the rete mirabile (RM), thereby simulating the pressure gradient and shunted blood flow of an AVM. Alginate and the reactive component, calcium chloride, were injected from double-lumen microcatheters to form a complete RM occlusion in the "acute swine" AVM model and a partial occlusion in a "survival swine" model. RESULTS: Angiographic and histological results verified complete occlusion of the left RM in acute animals when alginate was injected in stages. Partial RM occlusion in the survival animals blocked blood flow to the inferior portion of the RM but left flow open to the superior portion of the RM and the circle of Willis. One-week survival results showed that the alginate remained a stable occlusive material. Histological results showed a minor bioactive response and encapsulation of the alginate polymer, thereby increasing the stability and effective occlusion of the embolization material. CONCLUSION: Calcium alginate proved to be an effective endovascular occlusion material that blocked blood flow to the swine RM. The swine AVM models provided assessment of alginate injectability and effective occlusion and provided initial in vivo characteristics of alginate stability and biocompatibility.

Original languageEnglish (US)
Pages (from-to)453-459
Number of pages7
JournalNeurosurgery
Volume51
Issue number2
DOIs
StatePublished - Aug 1 2002
Externally publishedYes

Fingerprint

Intracranial Arteriovenous Malformations
Swine
Gels
Arteriovenous Malformations
Circle of Willis
alginic acid
Calcium Chloride
Polymers
Neck
Animal Models
Pressure

Keywords

  • Calcium alginate
  • Cerebral arteriovenous malformation
  • Embolization
  • Endovascular occlusion
  • Microcatheter injection
  • Rete mirabile

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

In vivo assessment of calcium alginate gel for endovascular embolization of a cerebral arteriovenous malformation model using the swine rete mirabile. / Becker, Timothy A.; Kipke, Daryl R.; Preul, Mark C.; Bichard, William D.; McDougall, Cameron G.; Bendok, Bernard; Levy, Elad I.; Guterman, Lee R.; Hopkins, L. Nelson; Ng, Perry P.; Higashida, Randall T.; Rosenwasser, Robert H.; Solomon, Robert A.

In: Neurosurgery, Vol. 51, No. 2, 01.08.2002, p. 453-459.

Research output: Contribution to journalArticle

Becker, TA, Kipke, DR, Preul, MC, Bichard, WD, McDougall, CG, Bendok, B, Levy, EI, Guterman, LR, Hopkins, LN, Ng, PP, Higashida, RT, Rosenwasser, RH & Solomon, RA 2002, 'In vivo assessment of calcium alginate gel for endovascular embolization of a cerebral arteriovenous malformation model using the swine rete mirabile', Neurosurgery, vol. 51, no. 2, pp. 453-459. https://doi.org/10.1097/00006123-200208000-00028
Becker, Timothy A. ; Kipke, Daryl R. ; Preul, Mark C. ; Bichard, William D. ; McDougall, Cameron G. ; Bendok, Bernard ; Levy, Elad I. ; Guterman, Lee R. ; Hopkins, L. Nelson ; Ng, Perry P. ; Higashida, Randall T. ; Rosenwasser, Robert H. ; Solomon, Robert A. / In vivo assessment of calcium alginate gel for endovascular embolization of a cerebral arteriovenous malformation model using the swine rete mirabile. In: Neurosurgery. 2002 ; Vol. 51, No. 2. pp. 453-459.
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T1 - In vivo assessment of calcium alginate gel for endovascular embolization of a cerebral arteriovenous malformation model using the swine rete mirabile

AU - Becker, Timothy A.

AU - Kipke, Daryl R.

AU - Preul, Mark C.

AU - Bichard, William D.

AU - McDougall, Cameron G.

AU - Bendok, Bernard

AU - Levy, Elad I.

AU - Guterman, Lee R.

AU - Hopkins, L. Nelson

AU - Ng, Perry P.

AU - Higashida, Randall T.

AU - Rosenwasser, Robert H.

AU - Solomon, Robert A.

PY - 2002/8/1

Y1 - 2002/8/1

N2 - OBJECTIVE: We sought to assess the stability of calcium alginate as an embolic agent in an animal model of a cerebral arteriovenous malformation (AVM). Swine cerebral AVM models were used to test the injectability, radiographic visualization, mechanical stability, and biocompatibility of calcium alginate as an occlusive agent. METHODS: The swine cerebral AVM model included a carotid-to-jugular anastomosis to increase flow to the rete mirabile (RM), thereby simulating the pressure gradient and shunted blood flow of an AVM. Alginate and the reactive component, calcium chloride, were injected from double-lumen microcatheters to form a complete RM occlusion in the "acute swine" AVM model and a partial occlusion in a "survival swine" model. RESULTS: Angiographic and histological results verified complete occlusion of the left RM in acute animals when alginate was injected in stages. Partial RM occlusion in the survival animals blocked blood flow to the inferior portion of the RM but left flow open to the superior portion of the RM and the circle of Willis. One-week survival results showed that the alginate remained a stable occlusive material. Histological results showed a minor bioactive response and encapsulation of the alginate polymer, thereby increasing the stability and effective occlusion of the embolization material. CONCLUSION: Calcium alginate proved to be an effective endovascular occlusion material that blocked blood flow to the swine RM. The swine AVM models provided assessment of alginate injectability and effective occlusion and provided initial in vivo characteristics of alginate stability and biocompatibility.

AB - OBJECTIVE: We sought to assess the stability of calcium alginate as an embolic agent in an animal model of a cerebral arteriovenous malformation (AVM). Swine cerebral AVM models were used to test the injectability, radiographic visualization, mechanical stability, and biocompatibility of calcium alginate as an occlusive agent. METHODS: The swine cerebral AVM model included a carotid-to-jugular anastomosis to increase flow to the rete mirabile (RM), thereby simulating the pressure gradient and shunted blood flow of an AVM. Alginate and the reactive component, calcium chloride, were injected from double-lumen microcatheters to form a complete RM occlusion in the "acute swine" AVM model and a partial occlusion in a "survival swine" model. RESULTS: Angiographic and histological results verified complete occlusion of the left RM in acute animals when alginate was injected in stages. Partial RM occlusion in the survival animals blocked blood flow to the inferior portion of the RM but left flow open to the superior portion of the RM and the circle of Willis. One-week survival results showed that the alginate remained a stable occlusive material. Histological results showed a minor bioactive response and encapsulation of the alginate polymer, thereby increasing the stability and effective occlusion of the embolization material. CONCLUSION: Calcium alginate proved to be an effective endovascular occlusion material that blocked blood flow to the swine RM. The swine AVM models provided assessment of alginate injectability and effective occlusion and provided initial in vivo characteristics of alginate stability and biocompatibility.

KW - Calcium alginate

KW - Cerebral arteriovenous malformation

KW - Embolization

KW - Endovascular occlusion

KW - Microcatheter injection

KW - Rete mirabile

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