Abstract
To determine if the renal 25-hydroxyvitamin D3 24-hydroxylase is active in addition to the intestinal 25-hydroxy-vitamin D3 24-hydroxylase in vivo in the rat, radiolabeled 25-hydroxyvitamin D3 was administered to normocalcemic, vitamin D-replete, enterocolectomized rats. Substantial amounts of 24,25-dihydroxyvitamin D3 were detected and the identity of the isolated plasma 24,25-dihydroxyvitamin D3 region in these animals was confirmed by coelution on high pressure liquid chromatography and periodate cleavage. This suggests that both intestinal and renal 25-hydroxyvitamin D3 24-hydroxylases are active in vivo in the rat.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1794-1796 |
| Number of pages | 3 |
| Journal | Endocrinology |
| Volume | 104 |
| Issue number | 6 |
| State | Published - 1979 |
| Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism