TY - JOUR
T1 - In vitro study of acute elevations of endoneurial pressure in mammalian peripheral nerve sheath
AU - Low, Phillip A.
N1 - Funding Information:
Abbreviation: EFP-endoneurial fluid pressure. ’ The investigator acknowledges with pleasure the helpful discussions with Drs. David Donald and Peter Dyck, Departments of Physiology and Biophysics, and Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minn. This investigation was supported in part by a Peripheral Neuropathy Clinical Center Grant from the National Institute of Neurological and Communicative Disorders and Stroke (NS14304) and by Mayo Funds.
PY - 1981/10
Y1 - 1981/10
N2 - In previous studies of peripheral nerve edema, endoneurial fluid pressure rarely exceeded 7 mm Hg for even the most edematous nerves. In a recent study a time-dependent reduction in elastic modulus was reported. However, because of the chronic nature of the studies, pressure and volume changes were not directly recorded from the same nerves. In the present study mammaliam perineurial compliance was directly studied in vitro. When compliance ( ΔV ΔP) was compared between nerves subjected to slow rates of ΔV (0.7μl/min) and fast rates (7 μl/min), mean values were reduced for all pressure intervals but did not become statistically significant because of considerable variability between nerves. However, in a separate series of experiments, when the same nerve sheath was consecutively subjected to these two rates of Δ V, compliance was consistently and significantly (P < 0.001, paired t test) greater for slow ΔV, confirming directly the importance of a time-dependent change in elastic modulus, i.e., a viscous modulus. A tentative physiologic-morphologic correlation is made. No evidence was found for norepinephrine- or acetylcholine-responsive contractile elements.
AB - In previous studies of peripheral nerve edema, endoneurial fluid pressure rarely exceeded 7 mm Hg for even the most edematous nerves. In a recent study a time-dependent reduction in elastic modulus was reported. However, because of the chronic nature of the studies, pressure and volume changes were not directly recorded from the same nerves. In the present study mammaliam perineurial compliance was directly studied in vitro. When compliance ( ΔV ΔP) was compared between nerves subjected to slow rates of ΔV (0.7μl/min) and fast rates (7 μl/min), mean values were reduced for all pressure intervals but did not become statistically significant because of considerable variability between nerves. However, in a separate series of experiments, when the same nerve sheath was consecutively subjected to these two rates of Δ V, compliance was consistently and significantly (P < 0.001, paired t test) greater for slow ΔV, confirming directly the importance of a time-dependent change in elastic modulus, i.e., a viscous modulus. A tentative physiologic-morphologic correlation is made. No evidence was found for norepinephrine- or acetylcholine-responsive contractile elements.
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U2 - 10.1016/0014-4886(81)90156-4
DO - 10.1016/0014-4886(81)90156-4
M3 - Article
C2 - 7286115
AN - SCOPUS:0019400745
SN - 0014-4886
VL - 74
SP - 160
EP - 169
JO - Experimental Neurology
JF - Experimental Neurology
IS - 1
ER -