In vitro studies of insulin-like growth factor I and bone

C. A. Conover

doi:10.1016/S1096-6374(00)80020-9

In vitro studies of insulin-like growth factor I and bone

C. A. Conover

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

Insulin-like growth factor I (IGF-I) stimulates osteoblastic cells in culture to proliferate and to synthesize bone matrix proteins. However, local IGF-I action is modulated by a family of IGF-binding proteins (IGFBPs) that, in turn, are modified by specific IGFBP proteases. All these components of the IGF-I regulatory system are present and operative in bone cells in vitro. (C) 2000 Harcourt Publishers Ltd.

Original language	English (US)
Pages (from-to)	S107-S110
Journal	Growth Hormone and IGF Research
Volume	10
Issue number	SUPPL. B
DOIs	https://doi.org/10.1016/S1096-6374(00)80020-9
State	Published - 2000

Keywords

IGFBP protease
IGFBP-4 and -5
Insulin-like growth factor I
Insulin-like growth factor-binding protein (IGFBP)
Osteoblast

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/S1096-6374(00)80020-9

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abstract = "Insulin-like growth factor I (IGF-I) stimulates osteoblastic cells in culture to proliferate and to synthesize bone matrix proteins. However, local IGF-I action is modulated by a family of IGF-binding proteins (IGFBPs) that, in turn, are modified by specific IGFBP proteases. All these components of the IGF-I regulatory system are present and operative in bone cells in vitro. (C) 2000 Harcourt Publishers Ltd.",

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N2 - Insulin-like growth factor I (IGF-I) stimulates osteoblastic cells in culture to proliferate and to synthesize bone matrix proteins. However, local IGF-I action is modulated by a family of IGF-binding proteins (IGFBPs) that, in turn, are modified by specific IGFBP proteases. All these components of the IGF-I regulatory system are present and operative in bone cells in vitro. (C) 2000 Harcourt Publishers Ltd.

AB - Insulin-like growth factor I (IGF-I) stimulates osteoblastic cells in culture to proliferate and to synthesize bone matrix proteins. However, local IGF-I action is modulated by a family of IGF-binding proteins (IGFBPs) that, in turn, are modified by specific IGFBP proteases. All these components of the IGF-I regulatory system are present and operative in bone cells in vitro. (C) 2000 Harcourt Publishers Ltd.

KW - IGFBP protease

KW - IGFBP-4 and -5

KW - Insulin-like growth factor I

KW - Insulin-like growth factor-binding protein (IGFBP)

KW - Osteoblast

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DO - 10.1016/S1096-6374(00)80020-9

M3 - Review article

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AN - SCOPUS:0033870125

SN - 1096-6374

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SP - S107-S110

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

IS - SUPPL. B

ER -

In vitro studies of insulin-like growth factor I and bone

Abstract

Keywords

ASJC Scopus subject areas

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