In vitro studies of insulin-like growth factor I and bone

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Insulin-like growth factor I (IGF-I) stimulates osteoblastic cells in culture to proliferate and to synthesize bone matrix proteins. However, local IGF-I action is modulated by a family of IGF-binding proteins (IGFBPs) that, in turn, are modified by specific IGFBP proteases. All these components of the IGF-I regulatory system are present and operative in bone cells in vitro. (C) 2000 Harcourt Publishers Ltd.

Original languageEnglish (US)
JournalGrowth Hormone and IGF Research
Volume10
Issue numberSUPPL. B
StatePublished - 2000

Fingerprint

Insulin-Like Growth Factor I
Insulin-Like Growth Factor Binding Proteins
Bone and Bones
Bone Matrix
Peptide Hydrolases
Cell Culture Techniques
In Vitro Techniques
Proteins

Keywords

  • IGFBP protease
  • IGFBP-4 and -5
  • Insulin-like growth factor I
  • Insulin-like growth factor-binding protein (IGFBP)
  • Osteoblast

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

In vitro studies of insulin-like growth factor I and bone. / Conover, Cheryl A.

In: Growth Hormone and IGF Research, Vol. 10, No. SUPPL. B, 2000.

Research output: Contribution to journalArticle

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