In vitro mechanical strength and in vivo bone ingrowth of a degrading polymeric composite biomaterial

Michael J Yaszemski, R. G. Payne, T. B. Aufdemorte, W. C. Hayes, R. Langer, A. G. Mikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Clinical situations that require techniques to fill defects of bone are common in the surgical care of Orthopaedic patients. There are three options currently available to the surgeon. This paper presents an alternative to these options: a novel, degradable, polymeric composite biomaterial. The biomaterial is sterilizable without loss of its mechanical and biological properties; available to the surgeon in the sterile operating field on short notice; moldable in a way that it can fill irregularly shaped defects; hardenable over a time span of ten to fifteen min; able to provide the reconstructed skeletal region with mechanical properties of the same order of magnitude as the replaced bones; degradable in weeks and replaceable by a new bone; and able to maintain a specified minimum mechanical strength during degradation and bone growth. The material is based on a linear polyester of propylene glycol and fumaric acid.

Original languageEnglish (US)
Title of host publicationMaterials Research Society Symposium - Proceedings
PublisherMaterials Research Society
Pages21-24
Number of pages4
Volume394
StatePublished - 1995
Externally publishedYes
EventProceedings of the 1995 MRS Spring Meeting - San Francisco, CA, USA
Duration: Apr 17 1995Apr 21 1995

Other

OtherProceedings of the 1995 MRS Spring Meeting
CitySan Francisco, CA, USA
Period4/17/954/21/95

Fingerprint

Biocompatible Materials
Biomaterials
Strength of materials
Bone
Composite materials
Propylene Glycol
Defects
Polyesters
Orthopedics
Glycols
Propylene
Degradation
Mechanical properties
Acids

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

Cite this

Yaszemski, M. J., Payne, R. G., Aufdemorte, T. B., Hayes, W. C., Langer, R., & Mikos, A. G. (1995). In vitro mechanical strength and in vivo bone ingrowth of a degrading polymeric composite biomaterial. In Materials Research Society Symposium - Proceedings (Vol. 394, pp. 21-24). Materials Research Society.

In vitro mechanical strength and in vivo bone ingrowth of a degrading polymeric composite biomaterial. / Yaszemski, Michael J; Payne, R. G.; Aufdemorte, T. B.; Hayes, W. C.; Langer, R.; Mikos, A. G.

Materials Research Society Symposium - Proceedings. Vol. 394 Materials Research Society, 1995. p. 21-24.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yaszemski, MJ, Payne, RG, Aufdemorte, TB, Hayes, WC, Langer, R & Mikos, AG 1995, In vitro mechanical strength and in vivo bone ingrowth of a degrading polymeric composite biomaterial. in Materials Research Society Symposium - Proceedings. vol. 394, Materials Research Society, pp. 21-24, Proceedings of the 1995 MRS Spring Meeting, San Francisco, CA, USA, 4/17/95.
Yaszemski MJ, Payne RG, Aufdemorte TB, Hayes WC, Langer R, Mikos AG. In vitro mechanical strength and in vivo bone ingrowth of a degrading polymeric composite biomaterial. In Materials Research Society Symposium - Proceedings. Vol. 394. Materials Research Society. 1995. p. 21-24
Yaszemski, Michael J ; Payne, R. G. ; Aufdemorte, T. B. ; Hayes, W. C. ; Langer, R. ; Mikos, A. G. / In vitro mechanical strength and in vivo bone ingrowth of a degrading polymeric composite biomaterial. Materials Research Society Symposium - Proceedings. Vol. 394 Materials Research Society, 1995. pp. 21-24
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