In vitro degradation of a poly(propylene fumarate)-based composite material

Michael J Yaszemski, Richard G. Payne, Wilson C. Hayes, Robert Langer, Antonios G. Mikos

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

We investigated the in vitro degradation of a novel degradable polymeric composite material being developed to function as a temporary replacement for trabecular bone. This material is based on a mixture of poly(propylene fumarate) cross-linked by N-vinyl pyrrolidone and includes sodium chloride and β-tricalcium phosphate. Using an in vitro test in simulated body fluids, the compressive strengths and compressive moduli of two composite materials increased with degradation time and remained above the minimum values acceptable for trabecular bone substitutes. A compressive strength of 21.3 (± 0.4) MPa and a compressive modulus of 696 (± 53) MPa were measured after twelve weeks for a composite material with initial strength of 18.0 (± 4.6) MPa and initial modulus of 113 (± 40) MPa. This unexpected phenomenon may prove to be useful for orthopaedic applications.

Original languageEnglish (US)
Pages (from-to)2127-2130
Number of pages4
JournalBiomaterials
Volume17
Issue number22
DOIs
StatePublished - Nov 1996

Fingerprint

Compressive Strength
Polypropylenes
Bone Substitutes
Degradation
Compressive strength
Bone
Composite materials
Body Fluids
Sodium Chloride
Orthopedics
Body fluids
Sodium chloride
Phosphates
Polymers
Cancellous Bone
In Vitro Techniques
poly(propylene fumarate)
tricalcium phosphate
N-vinyl-2-pyrrolidinone

Keywords

  • β-tricalcium phosphate
  • Bone substitutes
  • Composite materials
  • Degradable polymers
  • Poly(propylene fumarate)

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

In vitro degradation of a poly(propylene fumarate)-based composite material. / Yaszemski, Michael J; Payne, Richard G.; Hayes, Wilson C.; Langer, Robert; Mikos, Antonios G.

In: Biomaterials, Vol. 17, No. 22, 11.1996, p. 2127-2130.

Research output: Contribution to journalArticle

Yaszemski, Michael J ; Payne, Richard G. ; Hayes, Wilson C. ; Langer, Robert ; Mikos, Antonios G. / In vitro degradation of a poly(propylene fumarate)-based composite material. In: Biomaterials. 1996 ; Vol. 17, No. 22. pp. 2127-2130.
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