In vitro degradation of a poly(propylene fumarate)/β-tricalcium phosphate composite orthopaedic scaffold

Susan J. Peter, Jessica A. Nolley, Markus S. Widmer, John E. Merwin, Michael J Yaszemski, Alan W. Yasko, Paul S. Engel, Antonios G. Mikos

Research output: Contribution to journalArticle

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Abstract

This study involves investigating the in vitro degradation of a poly(propylene fumarate) (PPF) based composite material for orthopaedic applications. The effects of PPF molecular weight, PPF to vinyl monomer ratio, and solid phase content were studied. Mechanical properties, pore morphology, and sample mass loss were analyzed over a 12-week period of degradation. An initial increase in both compressive modulus and strength was seen for all formulations incorporating high molecular weight PPF. The PPF/monomer ratio was not seen to have a significant effect on any observations. Incorporation of β-tricalcium phosphate (β-TCP) resulted in an increase in mechanical properties and had no effect on weight loss. A composite formulation with an initial PPF/β-TCP ratio of 1.0 g/0.66 g exhibited an initial compressive strength of 2.60 MPa, which rose to 9.38 MPa at 3 weeks, and fell to 3.24 MPa at 7 weeks into the study. The initial modulus of 62.0 MPa for the same formulation increased to 250 MPa at 3 weeks, and fell to 63.7 MPa at 7 weeks. These studies further show that PPF/β-TCP composite scaffolds can be fabricated exhibiting initial mechanical properties similar to human trabecular bone and maintain these properties over several weeks of degradation.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalTissue Engineering
Volume3
Issue number2
DOIs
StatePublished - 1997

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Fumarates
Orthopedics
Scaffolds
Propylene
Polypropylenes
Phosphates
Degradation
Composite materials
Compressive Strength
Mechanical properties
Monomers
Molecular Weight
Molecular weight
Compressive strength
propylene
tricalcium phosphate
In Vitro Techniques
poly(propylene fumarate)
Weight Loss
Bone

ASJC Scopus subject areas

  • Biophysics
  • Cell Biology

Cite this

In vitro degradation of a poly(propylene fumarate)/β-tricalcium phosphate composite orthopaedic scaffold. / Peter, Susan J.; Nolley, Jessica A.; Widmer, Markus S.; Merwin, John E.; Yaszemski, Michael J; Yasko, Alan W.; Engel, Paul S.; Mikos, Antonios G.

In: Tissue Engineering, Vol. 3, No. 2, 1997, p. 207-215.

Research output: Contribution to journalArticle

Peter, SJ, Nolley, JA, Widmer, MS, Merwin, JE, Yaszemski, MJ, Yasko, AW, Engel, PS & Mikos, AG 1997, 'In vitro degradation of a poly(propylene fumarate)/β-tricalcium phosphate composite orthopaedic scaffold', Tissue Engineering, vol. 3, no. 2, pp. 207-215. https://doi.org/10.1089/ten.1997.3.207
Peter, Susan J. ; Nolley, Jessica A. ; Widmer, Markus S. ; Merwin, John E. ; Yaszemski, Michael J ; Yasko, Alan W. ; Engel, Paul S. ; Mikos, Antonios G. / In vitro degradation of a poly(propylene fumarate)/β-tricalcium phosphate composite orthopaedic scaffold. In: Tissue Engineering. 1997 ; Vol. 3, No. 2. pp. 207-215.
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