In vitro cell culture model of calcification: Molecular regulation of myofibroblast differentiation to an osteoblast phenotype

Nalini M. Rajamannan, Muzaffer Cicek, John R Hawse, Thomas C. Spelsberg, Malayannan Subramaniam

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The presence of calcification in the aortic valve is responsible for important prognostic information for the natural history of this disease [1, 2]. Although calcification in aortic valves has been described in the literature for over 100 years, little is known about the synthesis of bone matrix proteins in the aortic valve. Studies evaluating aortic valve calcification have focused on the expression of osteopontin (OP) expression in the mineralization zones of heavily calcified aortic valves obtained at autopsy and surgery [3, 4]. Furthermore, studies in cardiovascular calcification demonstrate parallel histologic findings in the valve and the vasculature in regards to the cellular abnormalities involved in the calcification [5].

Original languageEnglish (US)
Title of host publicationMolecular Biology of Valvular Heart Disease
PublisherSpringer-Verlag London Ltd
Pages13-20
Number of pages8
ISBN (Print)9781447163503, 9781447163497
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Medicine(all)

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    Rajamannan, N. M., Cicek, M., Hawse, J. R., Spelsberg, T. C., & Subramaniam, M. (2014). In vitro cell culture model of calcification: Molecular regulation of myofibroblast differentiation to an osteoblast phenotype. In Molecular Biology of Valvular Heart Disease (pp. 13-20). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-6350-3_2