In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonists

Govindarajan Rajagopalan, Moon M. Sen, Chella S. David

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Superantigen peptide antagonists failed to block T-cell activation and cytokine production as well as toxic shock induced by Staphylococcal enterotoxin B (SEB) in HLA class II transgenic mice. They also failed to inhibit the binding of SEB to HLA class II molecules as well as activation of human T lymphocytes in vitro.

Original languageEnglish (US)
Pages (from-to)6733-6737
Number of pages5
JournalInfection and Immunity
Volume72
Issue number11
DOIs
StatePublished - Nov 1 2004

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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