In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonists

Govindarajan Rajagopalan, Moon M. Sen, Chella S. David

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Superantigen peptide antagonists failed to block T-cell activation and cytokine production as well as toxic shock induced by Staphylococcal enterotoxin B (SEB) in HLA class II transgenic mice. They also failed to inhibit the binding of SEB to HLA class II molecules as well as activation of human T lymphocytes in vitro.

Original languageEnglish (US)
Pages (from-to)6733-6737
Number of pages5
JournalInfection and Immunity
Volume72
Issue number11
DOIs
StatePublished - Nov 2004

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Superantigens
T-Lymphocytes
Peptides
Septic Shock
Transgenic Mice
Cytokines
staphylococcal enterotoxin B
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonists. / Rajagopalan, Govindarajan; Sen, Moon M.; David, Chella S.

In: Infection and Immunity, Vol. 72, No. 11, 11.2004, p. 6733-6737.

Research output: Contribution to journalArticle

Rajagopalan, Govindarajan ; Sen, Moon M. ; David, Chella S. / In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonists. In: Infection and Immunity. 2004 ; Vol. 72, No. 11. pp. 6733-6737.
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