In vitro activity of tedizolid against linezolid-resistant staphylococci and enterococci

Stephanie L. Silva-Del Toro, Kerryl E. Greenwood-Quaintance, Robin Patel

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The tedizolid MIC of 27 clinical isolates of linezolid-resistant staphylococci and enterococci was determined. Tedizolid MICs were ≥1. μg/mL and were 4- to 32-fold lower than those of linezolid. Linezolid resistance mechanisms included G2576T 23S rRNA gene and rplC and rplD mutations.

Original languageEnglish (US)
JournalDiagnostic Microbiology and Infectious Disease
DOIs
StateAccepted/In press - Oct 23 2015

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Keywords

  • Antimicrobial resistance
  • Linezolid resistance
  • Multidrug resistance
  • Tedizolid resistance
  • Vancomycin resistant

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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