In vitro activity of oritavancin against planktonic and biofilm states of vancomycin-susceptible and vancomycin-resistant enterococci

Qun Yan, Melissa J. Karau, Robin Patel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We tested the in vitro activity of oritavancin against 60 vancomycin-susceptible enterococci (VSE) and 27 vancomycin-resistant enterococci (VRE). The oritavancin MIC ranged from ≤0.002 to 0.5 μg/mL; the minimum biofilm bactericidal concentration ranged from ≤0.002 to 2 μg/mL. Oritavancin has promising in vitro activity against VSE and VRE in both planktonic and biofilm states.

Original languageEnglish (US)
JournalDiagnostic Microbiology and Infectious Disease
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

oritavancin
Vancomycin
Biofilms
Enterococcus
Vancomycin-Resistant Enterococci
In Vitro Techniques

Keywords

  • Biofilm
  • Enterococcus faecalis
  • Enterococcus faecium
  • Oritavancin
  • VRE

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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title = "In vitro activity of oritavancin against planktonic and biofilm states of vancomycin-susceptible and vancomycin-resistant enterococci",
abstract = "We tested the in vitro activity of oritavancin against 60 vancomycin-susceptible enterococci (VSE) and 27 vancomycin-resistant enterococci (VRE). The oritavancin MIC ranged from ≤0.002 to 0.5 μg/mL; the minimum biofilm bactericidal concentration ranged from ≤0.002 to 2 μg/mL. Oritavancin has promising in vitro activity against VSE and VRE in both planktonic and biofilm states.",
keywords = "Biofilm, Enterococcus faecalis, Enterococcus faecium, Oritavancin, VRE",
author = "Qun Yan and Karau, {Melissa J.} and Robin Patel",
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AU - Karau, Melissa J.

AU - Patel, Robin

PY - 2018/1/1

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N2 - We tested the in vitro activity of oritavancin against 60 vancomycin-susceptible enterococci (VSE) and 27 vancomycin-resistant enterococci (VRE). The oritavancin MIC ranged from ≤0.002 to 0.5 μg/mL; the minimum biofilm bactericidal concentration ranged from ≤0.002 to 2 μg/mL. Oritavancin has promising in vitro activity against VSE and VRE in both planktonic and biofilm states.

AB - We tested the in vitro activity of oritavancin against 60 vancomycin-susceptible enterococci (VSE) and 27 vancomycin-resistant enterococci (VRE). The oritavancin MIC ranged from ≤0.002 to 0.5 μg/mL; the minimum biofilm bactericidal concentration ranged from ≤0.002 to 2 μg/mL. Oritavancin has promising in vitro activity against VSE and VRE in both planktonic and biofilm states.

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KW - Enterococcus faecalis

KW - Enterococcus faecium

KW - Oritavancin

KW - VRE

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