In vitro activity of oritavancin against biofilms of staphylococci isolated from prosthetic joint infection

Qun Yan, Melissa J. Karau, Robin Patel

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We tested the in vitro activity of oritavancin against 185 staphylococci associated with prosthetic joint infection, including 37 methicillin-resistant S. aureus, 67 methicillin-susceptible S. aureus, 59 methicillin-resistant S. epidermidis (MRSE), and 22 methicillin-susceptible S. epidermidis (MSSE) isolates. The oritavancin MIC50 for S. aureus and MSSE was 0.03 μg/mL, and for MRSE, it was 0.06 μg/mL; MIC90 for S. aureus and S. epidermidis was 0.12 μg/mL for both the methicillin-resistant and -susceptible subgroups. The oritavancin MBBC50 for S. aureus and S. epidermidis was 2 μg/mL for both the methicillin-resistant and -susceptible subgroups; the MBBC90 for S. aureus and MSSE was 4 μg/mL, and for MRSE, it was 8 μg/mL.

Original languageEnglish (US)
JournalDiagnostic Microbiology and Infectious Disease
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Biofilm
  • Oritavancin
  • Prosthetic joint infection
  • Staphylococci

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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