In vitro activity of linezolid against vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae

Robin Patel; Mark S. Rouse; Kerryl E. Piper; James M. Steckelberg

doi:10.1016/S0732-8893(99)00016-4

In vitro activity of linezolid against vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae

Robin Patel, Mark S. Rouse, Kerryl E. Piper, James M. Steckelberg

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

We report the activity of the new oxazolidinone antimicrobial agent linezolid against 37 clinical isolates of vancomycin-resistant enterococci (including organisms carrying the vanA, vanB, vanC-1, and vanC-2/3 genes), 26 clinical isolates of methicillin-resistant S. aureus and 20 clinical isolates of high-level penicillin-resistant S. pneumoniae. All isolates of vancomycin-resistant enterococci were inhibited by ≤ 4 ug/ml of linezolid. All isolates of methicillin-resistant S. aureus were inhibited by ≤ 8 ug/ml of linezolid. All isolates of penicillin-resistant S. pneumoniae were inhibited by ≤ 2 ug/ml of linezolid. Linezolid inhibits strains of multidrug resistant Gram-positive cocci in vitro at concentrations ≤ 8 ug/ml. Copyright (C) 1999 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	119-122
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/S0732-8893(99)00016-4
State	Published - Jun 1999

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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In vitro activity of linezolid against vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae. / Patel, Robin; Rouse, Mark S.; Piper, Kerryl E. et al.
In: Diagnostic Microbiology and Infectious Disease, Vol. 34, No. 2, 06.1999, p. 119-122.

Research output: Contribution to journal › Article › peer-review

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abstract = "We report the activity of the new oxazolidinone antimicrobial agent linezolid against 37 clinical isolates of vancomycin-resistant enterococci (including organisms carrying the vanA, vanB, vanC-1, and vanC-2/3 genes), 26 clinical isolates of methicillin-resistant S. aureus and 20 clinical isolates of high-level penicillin-resistant S. pneumoniae. All isolates of vancomycin-resistant enterococci were inhibited by ≤ 4 ug/ml of linezolid. All isolates of methicillin-resistant S. aureus were inhibited by ≤ 8 ug/ml of linezolid. All isolates of penicillin-resistant S. pneumoniae were inhibited by ≤ 2 ug/ml of linezolid. Linezolid inhibits strains of multidrug resistant Gram-positive cocci in vitro at concentrations ≤ 8 ug/ml. Copyright (C) 1999 Elsevier Science Inc.",

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In vitro activity of linezolid against vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae

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