TY - JOUR
T1 - In vitro activity of GAR-936 against vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae
AU - Patel, Robin
AU - Rouse, Mark S.
AU - Piper, Kerryl E.
AU - Steckelberg, James M.
PY - 2000
Y1 - 2000
N2 - We report the activity of the new glycylcycline antimicrobial agent GAR-936 against 37 clinical isolates of vancomycin-resistant enterococci (including organisms carrying the vanA, vanB, vanC-1, and vanC-2/3 genes), 26 clinical isolates of methicillin-resistant S. aureus and 30 clinical isolates of high-level penicillin-resistant S. pneumoniae. All isolates of vancomycin-resistant enterococci, methicillin-resistant S. aureus, and penicillin-resistant S. pneumoniae were inhibited by ≤ 1, ≤ 2, or ≤ 0.25 μg/ml of GAR-936, respectively. Time kill experiments using vancomycin-resistant enterococci did not demonstrate synergy or antagonism between 2 μg/ml of GAR-936 and 0.25 μg/ml of quinupristin/dalfopristin. (C) 2000 Elsevier Science Inc.
AB - We report the activity of the new glycylcycline antimicrobial agent GAR-936 against 37 clinical isolates of vancomycin-resistant enterococci (including organisms carrying the vanA, vanB, vanC-1, and vanC-2/3 genes), 26 clinical isolates of methicillin-resistant S. aureus and 30 clinical isolates of high-level penicillin-resistant S. pneumoniae. All isolates of vancomycin-resistant enterococci, methicillin-resistant S. aureus, and penicillin-resistant S. pneumoniae were inhibited by ≤ 1, ≤ 2, or ≤ 0.25 μg/ml of GAR-936, respectively. Time kill experiments using vancomycin-resistant enterococci did not demonstrate synergy or antagonism between 2 μg/ml of GAR-936 and 0.25 μg/ml of quinupristin/dalfopristin. (C) 2000 Elsevier Science Inc.
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U2 - 10.1016/S0732-8893(00)00193-0
DO - 10.1016/S0732-8893(00)00193-0
M3 - Article
C2 - 11109018
AN - SCOPUS:0033667340
SN - 0732-8893
VL - 38
SP - 177
EP - 179
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 3
ER -