TY - JOUR
T1 - In vitro activity of ceftaroline against staphylococci from prosthetic joint infection
AU - Park, Kyung Hwa
AU - Greenwood-Quaintance, Kerryl E.
AU - Patel, Robin
N1 - Funding Information:
This study was supported by Actavis (Allergan).
Publisher Copyright:
© 2016 Elsevier Inc.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - We tested the in vitro activity of ceftaroline by Etest against staphylococci recovered from patients with prosthetic joint infection, including 97 Staphylococcus aureus isolates (36%, oxacillin resistant) and 74 Staphylococcus epidermidis isolates (74%, oxacillin resistant). Ceftaroline inhibited all staphylococci at ≤0.5μg/mL. The ceftaroline MIC90/50 values for methicillin-susceptible S. aureus, methicillin-susceptible S. epidermidis, methicillin-resistant S. aureus, and methicillin-resistant S. epidermidis were 0.19/0.125, 0.094/0.047, 0.5/0.38, and 0.38/0.19μg/mL, respectively. Based on these in vitro findings, ceftaroline should be further evaluated as a potential therapeutic option for the treatment of prosthetic joint infection caused by methicillin-susceptible and methicillin-resistant S. aureus and S. epidermidis.
AB - We tested the in vitro activity of ceftaroline by Etest against staphylococci recovered from patients with prosthetic joint infection, including 97 Staphylococcus aureus isolates (36%, oxacillin resistant) and 74 Staphylococcus epidermidis isolates (74%, oxacillin resistant). Ceftaroline inhibited all staphylococci at ≤0.5μg/mL. The ceftaroline MIC90/50 values for methicillin-susceptible S. aureus, methicillin-susceptible S. epidermidis, methicillin-resistant S. aureus, and methicillin-resistant S. epidermidis were 0.19/0.125, 0.094/0.047, 0.5/0.38, and 0.38/0.19μg/mL, respectively. Based on these in vitro findings, ceftaroline should be further evaluated as a potential therapeutic option for the treatment of prosthetic joint infection caused by methicillin-susceptible and methicillin-resistant S. aureus and S. epidermidis.
KW - Ceftaroline
KW - Prosthetic joint infection
KW - Staphylococcus aureus
KW - Staphylococcus epidermidis
UR - http://www.scopus.com/inward/record.url?scp=84954402551&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84954402551&partnerID=8YFLogxK
U2 - 10.1016/j.diagmicrobio.2015.10.012
DO - 10.1016/j.diagmicrobio.2015.10.012
M3 - Article
C2 - 26602948
AN - SCOPUS:84954402551
SN - 0732-8893
VL - 84
SP - 141
EP - 143
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 2
ER -