In vitro activity of ceftaroline against staphylococci from prosthetic joint infection

Kyung Hwa Park, Kerryl E. Greenwood-Quaintance, Robin Patel

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We tested the in vitro activity of ceftaroline by Etest against staphylococci recovered from patients with prosthetic joint infection, including 97 Staphylococcus aureus isolates (36%, oxacillin resistant) and 74 Staphylococcus epidermidis isolates (74%, oxacillin resistant). Ceftaroline inhibited all staphylococci at ≤0.5μg/mL. The ceftaroline MIC90/50 values for methicillin-susceptible S. aureus, methicillin-susceptible S. epidermidis, methicillin-resistant S. aureus, and methicillin-resistant S. epidermidis were 0.19/0.125, 0.094/0.047, 0.5/0.38, and 0.38/0.19μg/mL, respectively. Based on these in vitro findings, ceftaroline should be further evaluated as a potential therapeutic option for the treatment of prosthetic joint infection caused by methicillin-susceptible and methicillin-resistant S. aureus and S. epidermidis.

Original languageEnglish (US)
Pages (from-to)141-143
Number of pages3
JournalDiagnostic Microbiology and Infectious Disease
Volume84
Issue number2
DOIs
StatePublished - Feb 1 2016

Keywords

  • Ceftaroline
  • Prosthetic joint infection
  • Staphylococcus aureus
  • Staphylococcus epidermidis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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