In Vitro Activity of a Hypochlorous Acid-Generating Electrochemical Bandage against Yeast Biofilms

Joseph Kletzer; Yash S. Raval; Abdelrhman Mohamed; Jayawant N. Mandrekar; Kerryl E. Greenwood-Quaintance; Haluk Beyenal; Robin Patel

doi:10.1128/aac.01166-22

In Vitro Activity of a Hypochlorous Acid-Generating Electrochemical Bandage against Yeast Biofilms

Joseph Kletzer, Yash S. Raval, Abdelrhman Mohamed, Jayawant N. Mandrekar, Kerryl E. Greenwood-Quaintance, Haluk Beyenal, Robin Patel

Research output: Contribution to journal › Article › peer-review

Abstract

The antibiofilm activity of a hypochlorous acid (HOCl)-producing electrochemical bandage (e-bandage) was assessed against 14 yeast isolates in vitro. The evaluated e-bandage was polarized at 11.5 V_Ag/AgCl to allow continuous production of HOCl. Time-dependent decreases in the biofilm CFU counts were observed for all isolates with e-bandage treatment. The results suggest that the described HOCl-producing e-bandage could serve as a potential alternative to traditional antifungal wound biofilm treatments.

Original language	English (US)
Journal	Antimicrobial Agents and Chemotherapy
Volume	67
Issue number	1
DOIs	https://doi.org/10.1128/aac.01166-22
State	Published - Jan 2023

Keywords

antibiofilm
electrochemical bandage
hypochlorous acid
membrane biofilm
wound infections

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/aac.01166-22

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abstract = "The antibiofilm activity of a hypochlorous acid (HOCl)-producing electrochemical bandage (e-bandage) was assessed against 14 yeast isolates in vitro. The evaluated e-bandage was polarized at 11.5 VAg/AgCl to allow continuous production of HOCl. Time-dependent decreases in the biofilm CFU counts were observed for all isolates with e-bandage treatment. The results suggest that the described HOCl-producing e-bandage could serve as a potential alternative to traditional antifungal wound biofilm treatments.",

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AU - Kletzer, Joseph

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AU - Mandrekar, Jayawant N.

AU - Greenwood-Quaintance, Kerryl E.

AU - Beyenal, Haluk

AU - Patel, Robin

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N2 - The antibiofilm activity of a hypochlorous acid (HOCl)-producing electrochemical bandage (e-bandage) was assessed against 14 yeast isolates in vitro. The evaluated e-bandage was polarized at 11.5 VAg/AgCl to allow continuous production of HOCl. Time-dependent decreases in the biofilm CFU counts were observed for all isolates with e-bandage treatment. The results suggest that the described HOCl-producing e-bandage could serve as a potential alternative to traditional antifungal wound biofilm treatments.

AB - The antibiofilm activity of a hypochlorous acid (HOCl)-producing electrochemical bandage (e-bandage) was assessed against 14 yeast isolates in vitro. The evaluated e-bandage was polarized at 11.5 VAg/AgCl to allow continuous production of HOCl. Time-dependent decreases in the biofilm CFU counts were observed for all isolates with e-bandage treatment. The results suggest that the described HOCl-producing e-bandage could serve as a potential alternative to traditional antifungal wound biofilm treatments.

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KW - electrochemical bandage

KW - hypochlorous acid

KW - membrane biofilm

KW - wound infections

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In Vitro Activity of a Hypochlorous Acid-Generating Electrochemical Bandage against Yeast Biofilms

Abstract

Keywords

ASJC Scopus subject areas

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