In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli

Shawn Vasoo; Scott A. Cunningham; Nicolynn C. Cole; Peggy C. Kohner; Sanjay R. Menon; Kevin M. Krause; Kelly A. Harris; Partha P. De; Tse Hsien Koh; Robin Patel

doi:10.1128/AAC.02019-15

In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli

Shawn Vasoo, Scott A. Cunningham, Nicolynn C. Cole, Peggy C. Kohner, Sanjay R. Menon, Kevin M. Krause, Kelly A. Harris, Partha P. De, Tse Hsien Koh, Robin Patel

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Among 177 carbapenemase-producing Gram-negative bacilli (108 KPC, 32 NDM, 11 IMP, 8 OXA-48, 4 OXA-181, 2 OXA-232, 5 IMI, 4 VIM, and 3 SME producers), aztreonam-avibactam was active against all isolates except two NDM producers with elevated MICs of 8/4 and 16/4 mg/liter; ceftazidime-avibactam was active against all KPC-, IMI-, SME-, and most OXA-48 group-producing isolates (93%) but not metallo-β-lactamase producers. Among older and contemporary antimicrobials, the most active were colistin, tigecycline, and fosfomycin, with overall susceptibilities of 88%, 79%, and 78%, respectively.

Original language	English (US)
Pages (from-to)	7842-7846
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	12
DOIs	https://doi.org/10.1128/AAC.02019-15
State	Published - Dec 1 2015

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Vasoo, S., Cunningham, S. A., Cole, N. C., Kohner, P. C., Menon, S. R., Krause, K. M., Harris, K. A., De, P. P., Koh, T. H., & Patel, R. (2015). In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli. Antimicrobial Agents and Chemotherapy, 59(12), 7842-7846. https://doi.org/10.1128/AAC.02019-15

In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli. / Vasoo, Shawn; Cunningham, Scott A.; Cole, Nicolynn C. et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 59, No. 12, 01.12.2015, p. 7842-7846.

Research output: Contribution to journal › Article › peer-review

Vasoo, S, Cunningham, SA, Cole, NC, Kohner, PC, Menon, SR, Krause, KM, Harris, KA, De, PP, Koh, TH & Patel, R 2015, 'In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli', Antimicrobial Agents and Chemotherapy, vol. 59, no. 12, pp. 7842-7846. https://doi.org/10.1128/AAC.02019-15

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abstract = "Among 177 carbapenemase-producing Gram-negative bacilli (108 KPC, 32 NDM, 11 IMP, 8 OXA-48, 4 OXA-181, 2 OXA-232, 5 IMI, 4 VIM, and 3 SME producers), aztreonam-avibactam was active against all isolates except two NDM producers with elevated MICs of 8/4 and 16/4 mg/liter; ceftazidime-avibactam was active against all KPC-, IMI-, SME-, and most OXA-48 group-producing isolates (93%) but not metallo-β-lactamase producers. Among older and contemporary antimicrobials, the most active were colistin, tigecycline, and fosfomycin, with overall susceptibilities of 88%, 79%, and 78%, respectively.",

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In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli

Abstract

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