In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli

Shawn Vasoo, Scott A. Cunningham, Nicolynn C. Cole, Peggy C. Kohner, Sanjay R. Menon, Kevin M. Krause, Kelly A. Harris, Partha P. De, Tse Hsien Koh, Robin Patel

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Among 177 carbapenemase-producing Gram-negative bacilli (108 KPC, 32 NDM, 11 IMP, 8 OXA-48, 4 OXA-181, 2 OXA-232, 5 IMI, 4 VIM, and 3 SME producers), aztreonam-avibactam was active against all isolates except two NDM producers with elevated MICs of 8/4 and 16/4 mg/liter; ceftazidime-avibactam was active against all KPC-, IMI-, SME-, and most OXA-48 group-producing isolates (93%) but not metallo-β-lactamase producers. Among older and contemporary antimicrobials, the most active were colistin, tigecycline, and fosfomycin, with overall susceptibilities of 88%, 79%, and 78%, respectively.

Original languageEnglish (US)
Pages (from-to)7842-7846
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number12
DOIs
StatePublished - Dec 1 2015

Fingerprint

Aztreonam
Anti-Infective Agents
Bacillus
Fosfomycin
Colistin
ceftazidime drug combination avibactam
Asp(5)-oxytocin
avibactam
In Vitro Techniques
carbapenemase

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli. / Vasoo, Shawn; Cunningham, Scott A.; Cole, Nicolynn C.; Kohner, Peggy C.; Menon, Sanjay R.; Krause, Kevin M.; Harris, Kelly A.; De, Partha P.; Koh, Tse Hsien; Patel, Robin.

In: Antimicrobial Agents and Chemotherapy, Vol. 59, No. 12, 01.12.2015, p. 7842-7846.

Research output: Contribution to journalArticle

Vasoo, Shawn ; Cunningham, Scott A. ; Cole, Nicolynn C. ; Kohner, Peggy C. ; Menon, Sanjay R. ; Krause, Kevin M. ; Harris, Kelly A. ; De, Partha P. ; Koh, Tse Hsien ; Patel, Robin. / In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli. In: Antimicrobial Agents and Chemotherapy. 2015 ; Vol. 59, No. 12. pp. 7842-7846.
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