In utero losartan withdrawal and subsequent development of fetal inferior vena cava thrombosis

Jamie N. Bakkum, Brian C. Brost, Keith L. Johansen, Bruce W. Johnston, William J. Watson

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

BACKGROUND: Angiotensin receptor blockers are antihypertensive medications prescribed by a wide variety of physicians, especially for patients with coexistent diabetes mellitus. Angiotensin receptor blockers, as well as angiotensin-converting enzyme inhibitors, are contraindicated in pregnancy. CASE: We describe the reversal of losartan-induced oligohydramnios at 27 weeks of gestation with subsequent development of fetal thrombosis and possible mechanism of action for this extremely rare in utero complication. CONCLUSION: This theory may help explain the fetal stillbirths in women taking this class of medications during the second and third trimester of pregnancy.

Original languageEnglish (US)
Pages (from-to)739-740
Number of pages2
JournalObstetrics and gynecology
Volume108
Issue number3 II
DOIs
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'In utero losartan withdrawal and subsequent development of fetal inferior vena cava thrombosis'. Together they form a unique fingerprint.

  • Cite this