In-utero exposure to smoking, alcohol, coffee, and tea and risk of strabismus

Tobias Torp-Pedersen, Heather A. Boyd, Gry Poulsen, Birgitte Haargaard, Jan Wohlfahrt, Jonathan M Holmes, Mads Melbye

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In a prospective, population-based cohort study, the authors investigated the effect of in-utero exposure to maternal smoking and consumption of alcohol, coffee, and tea on the risk of strabismus. They reviewed medical records for children in the Danish National Birth Cohort identified through national registers as possibly having strabismus. Relative risk estimates were adjusted for year of birth, social class, maternal smoking, maternal age at birth, and maternal coffee and tea consumption. The authors identified 1,321 cases of strabismus in a cohort of 96,842 Danish children born between 1996 and 2003. Maternal smoking was associated with a significantly elevated risk of strabismus in the child, increasing with number of cigarettes smoked per day (<5 cigarettes/day: relative risk (RR) = 0.95, 95% confidence interval (CI): 0.80, 1.14; 5-<10 cigarettes/day: RR = 1.38, 95% CI: 1.12, 1.70; ≥10 cigarettes/day: RR = 1.90, 95% CI: 1.57, 2.30). Nicotine replacement therapy was not associated with strabismus risk (RR = 1.22, 95% CI: 0.92, 1.61). Light maternal alcohol consumption was inversely associated with strabismus risk, whereas maternal coffee and tea drinking were not associated with strabismus risk. In conclusion, smoking during pregnancy is associated with an increased risk of strabismus in the offspring. Conversely, light alcohol consumption is associated with decreased risk.

Original languageEnglish (US)
Pages (from-to)868-875
Number of pages8
JournalAmerican Journal of Epidemiology
Volume171
Issue number8
DOIs
StatePublished - Apr 2010

Fingerprint

Strabismus
Coffee
Tea
Smoking
Alcohols
Tobacco Products
Mothers
Alcohol Drinking
Confidence Intervals
Parturition
Light
Maternal Exposure
Maternal Age
Nicotine
Social Class
Drinking
Medical Records
Cohort Studies

Keywords

  • Alcohol drinking
  • Smoking
  • Strabismus

ASJC Scopus subject areas

  • Epidemiology

Cite this

Torp-Pedersen, T., Boyd, H. A., Poulsen, G., Haargaard, B., Wohlfahrt, J., Holmes, J. M., & Melbye, M. (2010). In-utero exposure to smoking, alcohol, coffee, and tea and risk of strabismus. American Journal of Epidemiology, 171(8), 868-875. https://doi.org/10.1093/aje/kwq010

In-utero exposure to smoking, alcohol, coffee, and tea and risk of strabismus. / Torp-Pedersen, Tobias; Boyd, Heather A.; Poulsen, Gry; Haargaard, Birgitte; Wohlfahrt, Jan; Holmes, Jonathan M; Melbye, Mads.

In: American Journal of Epidemiology, Vol. 171, No. 8, 04.2010, p. 868-875.

Research output: Contribution to journalArticle

Torp-Pedersen, T, Boyd, HA, Poulsen, G, Haargaard, B, Wohlfahrt, J, Holmes, JM & Melbye, M 2010, 'In-utero exposure to smoking, alcohol, coffee, and tea and risk of strabismus', American Journal of Epidemiology, vol. 171, no. 8, pp. 868-875. https://doi.org/10.1093/aje/kwq010
Torp-Pedersen, Tobias ; Boyd, Heather A. ; Poulsen, Gry ; Haargaard, Birgitte ; Wohlfahrt, Jan ; Holmes, Jonathan M ; Melbye, Mads. / In-utero exposure to smoking, alcohol, coffee, and tea and risk of strabismus. In: American Journal of Epidemiology. 2010 ; Vol. 171, No. 8. pp. 868-875.
@article{7c6f40b5a9d041818511cce494be1d31,
title = "In-utero exposure to smoking, alcohol, coffee, and tea and risk of strabismus",
abstract = "In a prospective, population-based cohort study, the authors investigated the effect of in-utero exposure to maternal smoking and consumption of alcohol, coffee, and tea on the risk of strabismus. They reviewed medical records for children in the Danish National Birth Cohort identified through national registers as possibly having strabismus. Relative risk estimates were adjusted for year of birth, social class, maternal smoking, maternal age at birth, and maternal coffee and tea consumption. The authors identified 1,321 cases of strabismus in a cohort of 96,842 Danish children born between 1996 and 2003. Maternal smoking was associated with a significantly elevated risk of strabismus in the child, increasing with number of cigarettes smoked per day (<5 cigarettes/day: relative risk (RR) = 0.95, 95{\%} confidence interval (CI): 0.80, 1.14; 5-<10 cigarettes/day: RR = 1.38, 95{\%} CI: 1.12, 1.70; ≥10 cigarettes/day: RR = 1.90, 95{\%} CI: 1.57, 2.30). Nicotine replacement therapy was not associated with strabismus risk (RR = 1.22, 95{\%} CI: 0.92, 1.61). Light maternal alcohol consumption was inversely associated with strabismus risk, whereas maternal coffee and tea drinking were not associated with strabismus risk. In conclusion, smoking during pregnancy is associated with an increased risk of strabismus in the offspring. Conversely, light alcohol consumption is associated with decreased risk.",
keywords = "Alcohol drinking, Smoking, Strabismus",
author = "Tobias Torp-Pedersen and Boyd, {Heather A.} and Gry Poulsen and Birgitte Haargaard and Jan Wohlfahrt and Holmes, {Jonathan M} and Mads Melbye",
year = "2010",
month = "4",
doi = "10.1093/aje/kwq010",
language = "English (US)",
volume = "171",
pages = "868--875",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - In-utero exposure to smoking, alcohol, coffee, and tea and risk of strabismus

AU - Torp-Pedersen, Tobias

AU - Boyd, Heather A.

AU - Poulsen, Gry

AU - Haargaard, Birgitte

AU - Wohlfahrt, Jan

AU - Holmes, Jonathan M

AU - Melbye, Mads

PY - 2010/4

Y1 - 2010/4

N2 - In a prospective, population-based cohort study, the authors investigated the effect of in-utero exposure to maternal smoking and consumption of alcohol, coffee, and tea on the risk of strabismus. They reviewed medical records for children in the Danish National Birth Cohort identified through national registers as possibly having strabismus. Relative risk estimates were adjusted for year of birth, social class, maternal smoking, maternal age at birth, and maternal coffee and tea consumption. The authors identified 1,321 cases of strabismus in a cohort of 96,842 Danish children born between 1996 and 2003. Maternal smoking was associated with a significantly elevated risk of strabismus in the child, increasing with number of cigarettes smoked per day (<5 cigarettes/day: relative risk (RR) = 0.95, 95% confidence interval (CI): 0.80, 1.14; 5-<10 cigarettes/day: RR = 1.38, 95% CI: 1.12, 1.70; ≥10 cigarettes/day: RR = 1.90, 95% CI: 1.57, 2.30). Nicotine replacement therapy was not associated with strabismus risk (RR = 1.22, 95% CI: 0.92, 1.61). Light maternal alcohol consumption was inversely associated with strabismus risk, whereas maternal coffee and tea drinking were not associated with strabismus risk. In conclusion, smoking during pregnancy is associated with an increased risk of strabismus in the offspring. Conversely, light alcohol consumption is associated with decreased risk.

AB - In a prospective, population-based cohort study, the authors investigated the effect of in-utero exposure to maternal smoking and consumption of alcohol, coffee, and tea on the risk of strabismus. They reviewed medical records for children in the Danish National Birth Cohort identified through national registers as possibly having strabismus. Relative risk estimates were adjusted for year of birth, social class, maternal smoking, maternal age at birth, and maternal coffee and tea consumption. The authors identified 1,321 cases of strabismus in a cohort of 96,842 Danish children born between 1996 and 2003. Maternal smoking was associated with a significantly elevated risk of strabismus in the child, increasing with number of cigarettes smoked per day (<5 cigarettes/day: relative risk (RR) = 0.95, 95% confidence interval (CI): 0.80, 1.14; 5-<10 cigarettes/day: RR = 1.38, 95% CI: 1.12, 1.70; ≥10 cigarettes/day: RR = 1.90, 95% CI: 1.57, 2.30). Nicotine replacement therapy was not associated with strabismus risk (RR = 1.22, 95% CI: 0.92, 1.61). Light maternal alcohol consumption was inversely associated with strabismus risk, whereas maternal coffee and tea drinking were not associated with strabismus risk. In conclusion, smoking during pregnancy is associated with an increased risk of strabismus in the offspring. Conversely, light alcohol consumption is associated with decreased risk.

KW - Alcohol drinking

KW - Smoking

KW - Strabismus

UR - http://www.scopus.com/inward/record.url?scp=77950856703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950856703&partnerID=8YFLogxK

U2 - 10.1093/aje/kwq010

DO - 10.1093/aje/kwq010

M3 - Article

C2 - 20338975

AN - SCOPUS:77950856703

VL - 171

SP - 868

EP - 875

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 8

ER -