In the clinic: Ongoing clinical trials evaluating c-MET-inhibiting drugs

Neelesh Sharma, Alex A. Adjei

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

The c-MET (mesenchymal–epithelial transition factor) pathway is dysregulated in many human cancers and promotes tumor growth, invasion and dissemination. The c-MET receptor tyrosine kinase can be activated via gene mutation, gene amplification, protein overexpression and/or a ligand-dependent autocrine/paracrine loop. Abnormalities in c-MET signaling have been reported to correlate with poor clinical outcomes and drug resistance in patients with cancer. Significant progress has been made in advancement of c-MET pathway inhibitors through to clinical trials. A robust pipeline of high-quality inhibitors targeting different aspects of c-MET activation is currently being explored in phase I, II and III clinical trials across multiple tumor types. Preliminary data demonstrate promising clinical activity with these agents, along with an acceptable toxicity profile. In this manuscript, the pharmacological profile of drugs targeting the c-MET pathway and available data from ongoing clinical trials of these drugs are discussed.

Original languageEnglish (US)
Pages (from-to)S37-S50
JournalTherapeutic Advances in Medical Oncology
Volume3
Issue number1
DOIs
StatePublished - Nov 2011

Keywords

  • MetMAb
  • c-MET
  • cabozantinib
  • foretinib
  • tivantinib

ASJC Scopus subject areas

  • Oncology

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