TY - JOUR
T1 - In situ neoplasia in lymph node pathology
AU - Oishi, Naoki
AU - Montes-Moreno, Santiago
AU - Feldman, Andrew L.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/1
Y1 - 2018/1
N2 - In situ neoplasia represents the earliest form of malignant progression and is characterized by localization limited to the compartment corresponding to the cell of origin. Like other cancers, lymphoid neoplasms are considered to develop by multistep pathogenetic mechanisms. However, because of the circulating nature of lymphocytes, in situ lymphoid neoplasia may be difficult to identify histopathologically, and the compartment to which it is restricted may be physiological rather than strictly anatomical. The 2016 WHO classification of lymphoid neoplasms recognizes two in situ entities: in situ follicular neoplasia (ISFN) and in situ mantle cell neoplasia (ISMCN). This review summarizes the clinical features, histopathology, genetics, and differential diagnoses of these two entities, including distinction from both their overly malignant counterparts and a variety of reactive processes.
AB - In situ neoplasia represents the earliest form of malignant progression and is characterized by localization limited to the compartment corresponding to the cell of origin. Like other cancers, lymphoid neoplasms are considered to develop by multistep pathogenetic mechanisms. However, because of the circulating nature of lymphocytes, in situ lymphoid neoplasia may be difficult to identify histopathologically, and the compartment to which it is restricted may be physiological rather than strictly anatomical. The 2016 WHO classification of lymphoid neoplasms recognizes two in situ entities: in situ follicular neoplasia (ISFN) and in situ mantle cell neoplasia (ISMCN). This review summarizes the clinical features, histopathology, genetics, and differential diagnoses of these two entities, including distinction from both their overly malignant counterparts and a variety of reactive processes.
KW - 14)
KW - 18)
KW - Follicular lymphoma
KW - In situ follicular neoplasia
KW - In situ mantle cell neoplasia
KW - Lymphomagenesis
KW - Mantle cell lymphoma
KW - t(11
KW - t(14
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U2 - 10.1053/j.semdp.2017.11.001
DO - 10.1053/j.semdp.2017.11.001
M3 - Review article
C2 - 29129357
AN - SCOPUS:85033572172
SN - 0740-2570
VL - 35
SP - 76
EP - 83
JO - Seminars in Diagnostic Pathology
JF - Seminars in Diagnostic Pathology
IS - 1
ER -