In situ hybridization of nucleus basalis neurons shows increased β-amyloid mRNA in Alzheimer disease

M. L. Cohen, T. E. Golde, M. F. Usiak, L. H. Younkin, S. G. Younkin

Research output: Contribution to journalArticle

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Abstract

To determine which cells within the brain produce β-amyloid mRNA and to assess expression of the β-amyloid gene in Alzheimer disease, we analyzed brain tissue from Alzheimer and control patients by in situ hybridization. Our results demonstrate that β-amyloid mRNA is produced by neurons in the nucleus basalis of Meynert and cerebral cortex and that nucleus basalis perikarya from Alzheimer patients consistently hybridize more β-amyloid probe than those from controls. These observations support the hypothesis that increased expression of the β-amyloid gene plays an important role in the deposition of amyloid in the brains of patients with Alzheimer disease.

Original languageEnglish (US)
Pages (from-to)1227-1231
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number4
DOIs
StatePublished - Jan 1 1988

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