In-hospital neurologic deterioration following fractures of the ankylosed spine: A single-institution experience

Terry K. Schiefer, Brian D. Milligan, Colten D. Bracken, Jeffrey T. Jacob, William E. Krauss, Mark A. Pichelmann, Michelle J. Clarke

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Objective To determine the rate and severity of in-hospital neurologic deterioration following vertebral fractures of spinal hyperostosis. Methods A retrospective review of 92 fractures in 81 patients with diffuse idiopathic skeletal hyperostosis (42%) or ankylosing spondylitis (58%) was performed. Data on demographics, comorbidities, and fracture and treatment characteristics were recorded. Neurologic presentation and outcomes were categorized using American Spinal Injury Association grades and the modified Rankin Scale. Univariate and multivariate analyses were used to identify risk factors for neurologic deterioration or poor outcome (modified Rankin Scale 4-6). Results Most fractures (66%) occurred after falls of standing height or less. Presentation was delayed in 41% of patients (median 7 days), and diagnosis was delayed in 21% (median 8 days). Most fractures were extension (60%) or distraction (78%) injuries involving all 3 spinal columns. Median Subaxial Cervical Spine Injury Classification and Thoracolumbar Injury Severity Scale scores were 6 (interquartile range 5-7) and 7 (interquartile range 6-8), respectively. Of patients, 62% underwent open operative fusion either as initial therapy or after failed conservative treatment, 20% had percutaneous instrumentation, and 27% were treated in an external orthosis (52% required open fusion). Neurologic deterioration after presentation occurred in 7 patients (8.6%); 5 of these patients deteriorated after surgical treatment, constituting a 7.6% surgical risk. The presenting American Spinal Injury Association grade and patient age predicted poor outcome at 1-year outcome (P < 0.001). Death occurred in 17 patients within 1 year of injury (23%). Conclusions Neurologic deterioration during the initial hospitalization after spinal fractures in the setting of diffuse idiopathic skeletal hyperostosis or ankylosing spondylitis is common, and 1-year mortality is high.

Original languageEnglish (US)
Pages (from-to)775-783
Number of pages9
JournalWorld Neurosurgery
Volume83
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

Nervous System
Spine
Diffuse Idiopathic Skeletal Hyperostosis
Spinal Fractures
Ankylosing Spondylitis
Wounds and Injuries
Hyperostosis
Orthotic Devices
Injury Severity Score
Delayed Diagnosis
Comorbidity
Hospitalization
Therapeutics
Multivariate Analysis
Demography
Mortality

Keywords

  • Ankylosing spondylitis
  • Diffuse idiopathic hyperostosis
  • Spinal cord injury
  • Trauma

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Medicine(all)

Cite this

Schiefer, T. K., Milligan, B. D., Bracken, C. D., Jacob, J. T., Krauss, W. E., Pichelmann, M. A., & Clarke, M. J. (2015). In-hospital neurologic deterioration following fractures of the ankylosed spine: A single-institution experience. World Neurosurgery, 83(5), 775-783. https://doi.org/10.1016/j.wneu.2014.12.041

In-hospital neurologic deterioration following fractures of the ankylosed spine : A single-institution experience. / Schiefer, Terry K.; Milligan, Brian D.; Bracken, Colten D.; Jacob, Jeffrey T.; Krauss, William E.; Pichelmann, Mark A.; Clarke, Michelle J.

In: World Neurosurgery, Vol. 83, No. 5, 01.05.2015, p. 775-783.

Research output: Contribution to journalReview article

Schiefer, TK, Milligan, BD, Bracken, CD, Jacob, JT, Krauss, WE, Pichelmann, MA & Clarke, MJ 2015, 'In-hospital neurologic deterioration following fractures of the ankylosed spine: A single-institution experience', World Neurosurgery, vol. 83, no. 5, pp. 775-783. https://doi.org/10.1016/j.wneu.2014.12.041
Schiefer, Terry K. ; Milligan, Brian D. ; Bracken, Colten D. ; Jacob, Jeffrey T. ; Krauss, William E. ; Pichelmann, Mark A. ; Clarke, Michelle J. / In-hospital neurologic deterioration following fractures of the ankylosed spine : A single-institution experience. In: World Neurosurgery. 2015 ; Vol. 83, No. 5. pp. 775-783.
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title = "In-hospital neurologic deterioration following fractures of the ankylosed spine: A single-institution experience",
abstract = "Objective To determine the rate and severity of in-hospital neurologic deterioration following vertebral fractures of spinal hyperostosis. Methods A retrospective review of 92 fractures in 81 patients with diffuse idiopathic skeletal hyperostosis (42{\%}) or ankylosing spondylitis (58{\%}) was performed. Data on demographics, comorbidities, and fracture and treatment characteristics were recorded. Neurologic presentation and outcomes were categorized using American Spinal Injury Association grades and the modified Rankin Scale. Univariate and multivariate analyses were used to identify risk factors for neurologic deterioration or poor outcome (modified Rankin Scale 4-6). Results Most fractures (66{\%}) occurred after falls of standing height or less. Presentation was delayed in 41{\%} of patients (median 7 days), and diagnosis was delayed in 21{\%} (median 8 days). Most fractures were extension (60{\%}) or distraction (78{\%}) injuries involving all 3 spinal columns. Median Subaxial Cervical Spine Injury Classification and Thoracolumbar Injury Severity Scale scores were 6 (interquartile range 5-7) and 7 (interquartile range 6-8), respectively. Of patients, 62{\%} underwent open operative fusion either as initial therapy or after failed conservative treatment, 20{\%} had percutaneous instrumentation, and 27{\%} were treated in an external orthosis (52{\%} required open fusion). Neurologic deterioration after presentation occurred in 7 patients (8.6{\%}); 5 of these patients deteriorated after surgical treatment, constituting a 7.6{\%} surgical risk. The presenting American Spinal Injury Association grade and patient age predicted poor outcome at 1-year outcome (P < 0.001). Death occurred in 17 patients within 1 year of injury (23{\%}). Conclusions Neurologic deterioration during the initial hospitalization after spinal fractures in the setting of diffuse idiopathic skeletal hyperostosis or ankylosing spondylitis is common, and 1-year mortality is high.",
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T1 - In-hospital neurologic deterioration following fractures of the ankylosed spine

T2 - A single-institution experience

AU - Schiefer, Terry K.

AU - Milligan, Brian D.

AU - Bracken, Colten D.

AU - Jacob, Jeffrey T.

AU - Krauss, William E.

AU - Pichelmann, Mark A.

AU - Clarke, Michelle J.

PY - 2015/5/1

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N2 - Objective To determine the rate and severity of in-hospital neurologic deterioration following vertebral fractures of spinal hyperostosis. Methods A retrospective review of 92 fractures in 81 patients with diffuse idiopathic skeletal hyperostosis (42%) or ankylosing spondylitis (58%) was performed. Data on demographics, comorbidities, and fracture and treatment characteristics were recorded. Neurologic presentation and outcomes were categorized using American Spinal Injury Association grades and the modified Rankin Scale. Univariate and multivariate analyses were used to identify risk factors for neurologic deterioration or poor outcome (modified Rankin Scale 4-6). Results Most fractures (66%) occurred after falls of standing height or less. Presentation was delayed in 41% of patients (median 7 days), and diagnosis was delayed in 21% (median 8 days). Most fractures were extension (60%) or distraction (78%) injuries involving all 3 spinal columns. Median Subaxial Cervical Spine Injury Classification and Thoracolumbar Injury Severity Scale scores were 6 (interquartile range 5-7) and 7 (interquartile range 6-8), respectively. Of patients, 62% underwent open operative fusion either as initial therapy or after failed conservative treatment, 20% had percutaneous instrumentation, and 27% were treated in an external orthosis (52% required open fusion). Neurologic deterioration after presentation occurred in 7 patients (8.6%); 5 of these patients deteriorated after surgical treatment, constituting a 7.6% surgical risk. The presenting American Spinal Injury Association grade and patient age predicted poor outcome at 1-year outcome (P < 0.001). Death occurred in 17 patients within 1 year of injury (23%). Conclusions Neurologic deterioration during the initial hospitalization after spinal fractures in the setting of diffuse idiopathic skeletal hyperostosis or ankylosing spondylitis is common, and 1-year mortality is high.

AB - Objective To determine the rate and severity of in-hospital neurologic deterioration following vertebral fractures of spinal hyperostosis. Methods A retrospective review of 92 fractures in 81 patients with diffuse idiopathic skeletal hyperostosis (42%) or ankylosing spondylitis (58%) was performed. Data on demographics, comorbidities, and fracture and treatment characteristics were recorded. Neurologic presentation and outcomes were categorized using American Spinal Injury Association grades and the modified Rankin Scale. Univariate and multivariate analyses were used to identify risk factors for neurologic deterioration or poor outcome (modified Rankin Scale 4-6). Results Most fractures (66%) occurred after falls of standing height or less. Presentation was delayed in 41% of patients (median 7 days), and diagnosis was delayed in 21% (median 8 days). Most fractures were extension (60%) or distraction (78%) injuries involving all 3 spinal columns. Median Subaxial Cervical Spine Injury Classification and Thoracolumbar Injury Severity Scale scores were 6 (interquartile range 5-7) and 7 (interquartile range 6-8), respectively. Of patients, 62% underwent open operative fusion either as initial therapy or after failed conservative treatment, 20% had percutaneous instrumentation, and 27% were treated in an external orthosis (52% required open fusion). Neurologic deterioration after presentation occurred in 7 patients (8.6%); 5 of these patients deteriorated after surgical treatment, constituting a 7.6% surgical risk. The presenting American Spinal Injury Association grade and patient age predicted poor outcome at 1-year outcome (P < 0.001). Death occurred in 17 patients within 1 year of injury (23%). Conclusions Neurologic deterioration during the initial hospitalization after spinal fractures in the setting of diffuse idiopathic skeletal hyperostosis or ankylosing spondylitis is common, and 1-year mortality is high.

KW - Ankylosing spondylitis

KW - Diffuse idiopathic hyperostosis

KW - Spinal cord injury

KW - Trauma

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