Improving Single-Nucleotide Polymorphism-Based Fetal Fraction Estimation of Maternal Plasma Circulating Cell-Free DNA Using Bayesian Hierarchical Models

Mathematics

• Single nucleotide Polymorphism 100%
• Bayesian Hierarchical Model 99%
• Plasma 75%
• Cell 51%
• Screening 19%
• Hierarchical Modeling 16%
• Error Rate 13%
• Quantification 12%
• Genome 12%
• Mean Squared Error 11%
• Estimate 10%
• Extra-binomial Variation 10%
• Count 10%
• Roots 8%
• Quality Assurance 8%
• Pregnancy 8%
• High Throughput 8%
• Bayesian Modeling 7%
• Gold 7%
• Performance 6%
• Chromosome 6%
• Posterior distribution 5%
• Coverage 5%
• Outlier 5%
• Extremes 5%
• Proportion 5%
• Character 4%
• Strategy 4%
• Dependent 3%
• Standards 3%
• Model 1%

Engineering & Materials Science

• Polymorphism 86%
• Nucleotides 86%
• DNA 71%
• Plasmas 63%
• Assays 27%
• Screening 16%
• Genomics 12%
• Chromosomes 6%
• Quality assurance 6%
• Throughput 4%

Medicine & Life Sciences

• Cell-Free Nucleic Acids 87%
• Plasma Cells 69%
• Single Nucleotide Polymorphism 58%
• Mothers 44%
• Noninvasive Prenatal Testing 27%
• Whole Genome Sequencing 13%
• High-Throughput Nucleotide Sequencing 11%
• Bias 7%
• Y Chromosome 7%
• X Chromosome 6%
• Fetus 4%
• Alleles 4%
• Technology 3%
• Pregnancy 3%