Improving patient care through molecular diagnostics

Edith A. Perez, Lajos Pusztai, Marc Van De Vijver

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Traditional cancer diagnostic techniques include assessment of histologic appearance, identification of specific tumor subtypes, tumor grading, assessment of lymph node status, and presence of metastasis. These are useful for initial evaluation, but are limited in their ability to predict response to treatment and/or risk of experiencing adverse events to particular treatments. Recently, there has been considerable progress in molecular diagnostics in this area. Using molecular-based technologies, it is now possible to identify some patients with an inherited risk of developing breast cancer, and to more accurately assess the prognosis of those who already have developed the disease. Various techniques are also available or under investigation to help select patients who are most likely to respond to certain types of treatment. At present, this includes diagnostic tests to identify single tumor markers for which specific therapies are available, such as estrogen receptor and HER2. Diagnostic systems that allow simultaneous assessment of multiple markers, such as DNA microarrays and proteomics, are currently being validated. The use of these systems will allow further development of customized therapies directed toward the particular molecular defects in a given cancer.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalSeminars in Oncology
Volume31
Issue numberSUPPL. 10
DOIs
StatePublished - Oct 2004

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Molecular Pathology
Patient Care
Therapeutics
Neoplasms
Neoplasm Grading
Tumor Biomarkers
Oligonucleotide Array Sequence Analysis
Routine Diagnostic Tests
Estrogen Receptors
Proteomics
Lymph Nodes
Breast Neoplasms
Neoplasm Metastasis
Technology

ASJC Scopus subject areas

  • Oncology

Cite this

Perez, E. A., Pusztai, L., & Van De Vijver, M. (2004). Improving patient care through molecular diagnostics. Seminars in Oncology, 31(SUPPL. 10), 14-20. https://doi.org/10.1053/j.seminoncol.2004.07.017

Improving patient care through molecular diagnostics. / Perez, Edith A.; Pusztai, Lajos; Van De Vijver, Marc.

In: Seminars in Oncology, Vol. 31, No. SUPPL. 10, 10.2004, p. 14-20.

Research output: Contribution to journalArticle

Perez, EA, Pusztai, L & Van De Vijver, M 2004, 'Improving patient care through molecular diagnostics', Seminars in Oncology, vol. 31, no. SUPPL. 10, pp. 14-20. https://doi.org/10.1053/j.seminoncol.2004.07.017
Perez, Edith A. ; Pusztai, Lajos ; Van De Vijver, Marc. / Improving patient care through molecular diagnostics. In: Seminars in Oncology. 2004 ; Vol. 31, No. SUPPL. 10. pp. 14-20.
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