Improving Outcomes for Esophageal Cancer using Proton Beam Therapy

Michael D. Chuong, Christopher Hallemeier, Salma K. Jabbour, Jen Yu, Shahed Badiyan, Kenneth W. Merrell, Mark V. Mishra, Heng Li, Vivek Verma, Steven H. Lin

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Radiation therapy (RT) plays an essential role in the management of esophageal cancer. Because the esophagus is a centrally located thoracic structure there is a need to balance the delivery of appropriately high dose to the target while minimizing dose to nearby critical structures. Radiation dose received by these critical structures, especially the heart and lungs, may lead to clinically significant toxicities, including pneumonitis, pericarditis, and myocardial infarction. Although technological advancements in photon RT delivery like intensity modulated RT have decreased the risk of such toxicities, a growing body of evidence indicates that further risk reductions are achieved with proton beam therapy (PBT). Herein we review the published dosimetric and clinical PBT literature for esophageal cancer, including motion management considerations, the potential for reirradiation, radiation dose escalation, and ongoing esophageal PBT clinical trials. We also consider the potential cost-effectiveness of PBT relative to photon RT.

Original languageEnglish (US)
Pages (from-to)488-497
Number of pages10
JournalInternational Journal of Radiation Oncology Biology Physics
Volume95
Issue number1
DOIs
StatePublished - May 1 2016

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ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Chuong, M. D., Hallemeier, C., Jabbour, S. K., Yu, J., Badiyan, S., Merrell, K. W., Mishra, M. V., Li, H., Verma, V., & Lin, S. H. (2016). Improving Outcomes for Esophageal Cancer using Proton Beam Therapy. International Journal of Radiation Oncology Biology Physics, 95(1), 488-497. https://doi.org/10.1016/j.ijrobp.2015.11.043