Improvement of myelopathy in Sjogren's syndrome with chlorambucil and prednisone therapy

R. Alan Wright; J. Desmond O'Duffy; Moses Rodriguez

doi:10.1212/wnl.52.2.386

Improvement of myelopathy in Sjogren's syndrome with chlorambucil and prednisone therapy

R. Alan Wright, J. Desmond O'Duffy, Moses Rodriguez

Neurology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The authors present a patient with Sjogren's syndrome with a fluctuating and then progressive myelopathic syndrome, and optic nerve involvement. Treatment with chlorambucil and prednisone improved the patient's function from being wheelchair bound to walking unaided. Spinal MRI showed multiple, extensive intraparenchymal areas of abnormal T2-weighted signal intensity, gadolinium enhancement, and cord swelling, which also improved during the period of treatment.

Original language	English (US)
Pages (from-to)	386-388
Number of pages	3
Journal	Neurology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1212/wnl.52.2.386
State	Published - Jan 15 1999

ASJC Scopus subject areas

Clinical Neurology

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abstract = "The authors present a patient with Sjogren's syndrome with a fluctuating and then progressive myelopathic syndrome, and optic nerve involvement. Treatment with chlorambucil and prednisone improved the patient's function from being wheelchair bound to walking unaided. Spinal MRI showed multiple, extensive intraparenchymal areas of abnormal T2-weighted signal intensity, gadolinium enhancement, and cord swelling, which also improved during the period of treatment.",

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AU - O'Duffy, J. Desmond

AU - Rodriguez, Moses

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N2 - The authors present a patient with Sjogren's syndrome with a fluctuating and then progressive myelopathic syndrome, and optic nerve involvement. Treatment with chlorambucil and prednisone improved the patient's function from being wheelchair bound to walking unaided. Spinal MRI showed multiple, extensive intraparenchymal areas of abnormal T2-weighted signal intensity, gadolinium enhancement, and cord swelling, which also improved during the period of treatment.

AB - The authors present a patient with Sjogren's syndrome with a fluctuating and then progressive myelopathic syndrome, and optic nerve involvement. Treatment with chlorambucil and prednisone improved the patient's function from being wheelchair bound to walking unaided. Spinal MRI showed multiple, extensive intraparenchymal areas of abnormal T2-weighted signal intensity, gadolinium enhancement, and cord swelling, which also improved during the period of treatment.

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Improvement of myelopathy in Sjogren's syndrome with chlorambucil and prednisone therapy

Abstract

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