Improvement in Visual Fields after Treatment of Intracranial Meningioma with Bevacizumab

K. Ina Ly, Steven R. Hamilton, Robert C. Rostomily, Jason K. Rockhill, MacIej M. Mrugala

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

High-grade (World Health Organization [WHO] Grade II and III) meningiomas constitute a minority of all meningioma cases but are associated with significant morbidity and mortality, due to more aggressive tumor behavior and a tendency to recur despite standard therapy with resection and radiotherapy. They display a higher degree of vascularity than WHO Grade I meningiomas and produce angiogenic and growth factors, including vascular endothelial growth factor (VEGF). Bevacizumab, a humanized monoclonal antibody against VEGF-A, has been used in the treatment of recurrent or progressive meningiomas resistant to standard therapy. We report a patient with a recurrent left frontotemporal meningioma and associated-vision loss who experienced substantial visual field recovery after 3 cycles of bevacizumab. In addition, we provide a review of the literature regarding the efficacy of bevacizumab in the treatment of recurrent meningiomas.

Original languageEnglish (US)
Pages (from-to)382-386
Number of pages5
JournalJournal of Neuro-Ophthalmology
Volume35
Issue number4
DOIs
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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