Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine

A. J. Flach, L. M. Jampol, D. Weinberg, M. C. Kraff, L. A. Yannuzzi, R. V. Campo, A. C. Neumann, H. P. Cupples, W. H. Lefler, J. S. Pulido, C. Lavelle

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Abstract

Ketorolac tromethamine 0.5% ophthalmic solution treatment was compared to placebo treatment in 120 patients with chronic aphakic or pseudophakic cystoid macular edema (six-month or more duration of distance visual acuity of 20/40 or less and angiographic evidence of cystoid changes) during a four-to five-month double-masked, multicenter study in which patients were randomly assigned. A statistically significant improvement in distance visual acuity (two lines or more) was observed in the ketorolac-treated group as compared to the placebo-treated group after 30 days (P = .038), 60 days (P = .017), and 90 days (P = .008) of treatment. This improvement in visual acuity remained statistically significant one month after cessation of treatment (P = .001). Nine ketorolac-treated patients and two placebo-treated patients demonstrated a decrease in visual acuity one month after treatment was discontinued. Seven of the nine ketorolac-treated patients experienced an improvement in visual acuity after retreatment as compared to none of the placebo-treated patients. This study offers evidence for a more optimistic outlook in the medical treatment of chronic aphakic and pseudophakic cystoid macular edema.

Original languageEnglish (US)
Pages (from-to)514-519
Number of pages6
JournalAmerican journal of ophthalmology
Volume112
Issue number5
DOIs
StatePublished - Jan 1 1991

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ASJC Scopus subject areas

  • Ophthalmology

Cite this

Flach, A. J., Jampol, L. M., Weinberg, D., Kraff, M. C., Yannuzzi, L. A., Campo, R. V., Neumann, A. C., Cupples, H. P., Lefler, W. H., Pulido, J. S., & Lavelle, C. (1991). Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine. American journal of ophthalmology, 112(5), 514-519. https://doi.org/10.1016/S0002-9394(14)76851-5