Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine

A. J. Flach; L. M. Jampol; D. Weinberg; M. C. Kraff; L. A. Yannuzzi; R. V. Campo; A. C. Neumann; H. P. Cupples; W. H. Lefler; J. S. Pulido; C. Lavelle

doi:10.1016/S0002-9394(14)76851-5

Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine

A. J. Flach, L. M. Jampol, D. Weinberg, M. C. Kraff, L. A. Yannuzzi, R. V. Campo, A. C. Neumann, H. P. Cupples, W. H. Lefler, J. S. Pulido, C. Lavelle

Ophthalmology

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Abstract

Ketorolac tromethamine 0.5% ophthalmic solution treatment was compared to placebo treatment in 120 patients with chronic aphakic or pseudophakic cystoid macular edema (six-month or more duration of distance visual acuity of 20/40 or less and angiographic evidence of cystoid changes) during a four-to five-month double-masked, multicenter study in which patients were randomly assigned. A statistically significant improvement in distance visual acuity (two lines or more) was observed in the ketorolac-treated group as compared to the placebo-treated group after 30 days (P = .038), 60 days (P = .017), and 90 days (P = .008) of treatment. This improvement in visual acuity remained statistically significant one month after cessation of treatment (P = .001). Nine ketorolac-treated patients and two placebo-treated patients demonstrated a decrease in visual acuity one month after treatment was discontinued. Seven of the nine ketorolac-treated patients experienced an improvement in visual acuity after retreatment as compared to none of the placebo-treated patients. This study offers evidence for a more optimistic outlook in the medical treatment of chronic aphakic and pseudophakic cystoid macular edema.

Original language	English (US)
Pages (from-to)	514-519
Number of pages	6
Journal	American journal of ophthalmology
Volume	112
Issue number	5
DOIs	https://doi.org/10.1016/S0002-9394(14)76851-5
State	Published - 1991

ASJC Scopus subject areas

Ophthalmology

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Flach, A. J., Jampol, L. M., Weinberg, D., Kraff, M. C., Yannuzzi, L. A., Campo, R. V., Neumann, A. C., Cupples, H. P., Lefler, W. H., Pulido, J. S., & Lavelle, C. (1991). Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine. American journal of ophthalmology, 112(5), 514-519. https://doi.org/10.1016/S0002-9394(14)76851-5

Flach, AJ, Jampol, LM, Weinberg, D, Kraff, MC, Yannuzzi, LA, Campo, RV, Neumann, AC, Cupples, HP, Lefler, WH, Pulido, JS & Lavelle, C 1991, 'Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine', American journal of ophthalmology, vol. 112, no. 5, pp. 514-519. https://doi.org/10.1016/S0002-9394(14)76851-5

@article{a66068cbba3d426cab242935f66704d3,

title = "Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine",

abstract = "Ketorolac tromethamine 0.5% ophthalmic solution treatment was compared to placebo treatment in 120 patients with chronic aphakic or pseudophakic cystoid macular edema (six-month or more duration of distance visual acuity of 20/40 or less and angiographic evidence of cystoid changes) during a four-to five-month double-masked, multicenter study in which patients were randomly assigned. A statistically significant improvement in distance visual acuity (two lines or more) was observed in the ketorolac-treated group as compared to the placebo-treated group after 30 days (P = .038), 60 days (P = .017), and 90 days (P = .008) of treatment. This improvement in visual acuity remained statistically significant one month after cessation of treatment (P = .001). Nine ketorolac-treated patients and two placebo-treated patients demonstrated a decrease in visual acuity one month after treatment was discontinued. Seven of the nine ketorolac-treated patients experienced an improvement in visual acuity after retreatment as compared to none of the placebo-treated patients. This study offers evidence for a more optimistic outlook in the medical treatment of chronic aphakic and pseudophakic cystoid macular edema.",

author = "Flach, {A. J.} and Jampol, {L. M.} and D. Weinberg and Kraff, {M. C.} and Yannuzzi, {L. A.} and Campo, {R. V.} and Neumann, {A. C.} and Cupples, {H. P.} and Lefler, {W. H.} and Pulido, {J. S.} and C. Lavelle",

note = "Funding Information: From the Department of Ophthalmology, University of California at San Francisco and the Ophthalmology Service at the Veterans Administration Hospital, San Francisco (Dr. Flach); Department of Ophthalmology, Northwestern University, Chicago (Drs. [arnpol and Weinberg); University of lIIinois Eye and Ear Infirmary, Chicago (Dr. Kraff); Manhattan Eye, Ear and Throat Hospital and Department of Ophthalmology, Columbia University Medical Center, New York (Dr. Yannuzzi); Mesa, Arizona (Dr. Campo); Deland, Florida (Dr. Neumann); Georgetown University Medical Center, Washington, D.C. (Dr. Cupples); Hickory, North Carolina (Dr. Lefler); University of Iowa, Iowa City (Dr. Pulido); and Syntex Research, Palo Alto, California (Ms. Lavelle). This study was supported by Syntex Research, Palo Alto, California. This study was presented at the annual meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Florida, April 28, 1991.",

year = "1991",

doi = "10.1016/S0002-9394(14)76851-5",

language = "English (US)",

volume = "112",

pages = "514--519",

journal = "American journal of ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

number = "5",

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TY - JOUR

T1 - Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine

AU - Flach, A. J.

AU - Jampol, L. M.

AU - Weinberg, D.

AU - Kraff, M. C.

AU - Yannuzzi, L. A.

AU - Campo, R. V.

AU - Neumann, A. C.

AU - Cupples, H. P.

AU - Lefler, W. H.

AU - Pulido, J. S.

AU - Lavelle, C.

N1 - Funding Information: From the Department of Ophthalmology, University of California at San Francisco and the Ophthalmology Service at the Veterans Administration Hospital, San Francisco (Dr. Flach); Department of Ophthalmology, Northwestern University, Chicago (Drs. [arnpol and Weinberg); University of lIIinois Eye and Ear Infirmary, Chicago (Dr. Kraff); Manhattan Eye, Ear and Throat Hospital and Department of Ophthalmology, Columbia University Medical Center, New York (Dr. Yannuzzi); Mesa, Arizona (Dr. Campo); Deland, Florida (Dr. Neumann); Georgetown University Medical Center, Washington, D.C. (Dr. Cupples); Hickory, North Carolina (Dr. Lefler); University of Iowa, Iowa City (Dr. Pulido); and Syntex Research, Palo Alto, California (Ms. Lavelle). This study was supported by Syntex Research, Palo Alto, California. This study was presented at the annual meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Florida, April 28, 1991.

PY - 1991

Y1 - 1991

N2 - Ketorolac tromethamine 0.5% ophthalmic solution treatment was compared to placebo treatment in 120 patients with chronic aphakic or pseudophakic cystoid macular edema (six-month or more duration of distance visual acuity of 20/40 or less and angiographic evidence of cystoid changes) during a four-to five-month double-masked, multicenter study in which patients were randomly assigned. A statistically significant improvement in distance visual acuity (two lines or more) was observed in the ketorolac-treated group as compared to the placebo-treated group after 30 days (P = .038), 60 days (P = .017), and 90 days (P = .008) of treatment. This improvement in visual acuity remained statistically significant one month after cessation of treatment (P = .001). Nine ketorolac-treated patients and two placebo-treated patients demonstrated a decrease in visual acuity one month after treatment was discontinued. Seven of the nine ketorolac-treated patients experienced an improvement in visual acuity after retreatment as compared to none of the placebo-treated patients. This study offers evidence for a more optimistic outlook in the medical treatment of chronic aphakic and pseudophakic cystoid macular edema.

AB - Ketorolac tromethamine 0.5% ophthalmic solution treatment was compared to placebo treatment in 120 patients with chronic aphakic or pseudophakic cystoid macular edema (six-month or more duration of distance visual acuity of 20/40 or less and angiographic evidence of cystoid changes) during a four-to five-month double-masked, multicenter study in which patients were randomly assigned. A statistically significant improvement in distance visual acuity (two lines or more) was observed in the ketorolac-treated group as compared to the placebo-treated group after 30 days (P = .038), 60 days (P = .017), and 90 days (P = .008) of treatment. This improvement in visual acuity remained statistically significant one month after cessation of treatment (P = .001). Nine ketorolac-treated patients and two placebo-treated patients demonstrated a decrease in visual acuity one month after treatment was discontinued. Seven of the nine ketorolac-treated patients experienced an improvement in visual acuity after retreatment as compared to none of the placebo-treated patients. This study offers evidence for a more optimistic outlook in the medical treatment of chronic aphakic and pseudophakic cystoid macular edema.

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Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine

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