TY - JOUR
T1 - Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5-HT3 receptor antagonist
AU - Camilleri, M.
AU - Mayer, E. A.
AU - Drossman, D. A.
AU - Heath, A.
AU - Dukes, G. E.
AU - McSorley, D.
AU - Kong, S.
AU - Mangel, A. W.
AU - Northcutt, A. R.
PY - 1999
Y1 - 1999
N2 - Background: No currently available treatment provides consistent relief of irritable bowel syndrome. Colonic sensory and motor function are modulated partly through 5HT3-receptors. Aim: To evaluate effects of the 5HT3-receptor antagonist, alosetron, in irritable bowel syndrome. Methods: Randomized, double-blind, placebo-controlled, dose-ranging (1, 2, 4, 8 mg b.d. alosetron), 12-week trial in 370 patients with diarrhoea-predominant or alternating constipation and diarrhoea irritable bowel syndrome. Weekly measurement of adequate relief was the key endpoint: other irritable bowel syndrome symptoms were collected daily using an electronic phone system. Results: Alosetron (1 mg or 2 mg b.d.) significantly (P < 0.05 vs. placebo) increased the proportion of females, but not males, reporting adequate relief. Stool consistency, frequency and percentage days with urgency improved over placebo (P < 0.05) within the first month with all doses of alosetron, and persisted throughout the trial with all doses in female patients. With 1 mg b.d. alosetron, females had improved stool consistency and urgency within the first week, and adequate relief and improved stool frequency within the first 2 weeks. There was no consistent improvement in bowel function among male patients. Conclusion: In female irritable bower syndrome patients with predominant diarrhoea or alternating constipation and diarrhoea, alosetron is effective in treatment of abdominal pain and discomfort and bowel-related symptoms.
AB - Background: No currently available treatment provides consistent relief of irritable bowel syndrome. Colonic sensory and motor function are modulated partly through 5HT3-receptors. Aim: To evaluate effects of the 5HT3-receptor antagonist, alosetron, in irritable bowel syndrome. Methods: Randomized, double-blind, placebo-controlled, dose-ranging (1, 2, 4, 8 mg b.d. alosetron), 12-week trial in 370 patients with diarrhoea-predominant or alternating constipation and diarrhoea irritable bowel syndrome. Weekly measurement of adequate relief was the key endpoint: other irritable bowel syndrome symptoms were collected daily using an electronic phone system. Results: Alosetron (1 mg or 2 mg b.d.) significantly (P < 0.05 vs. placebo) increased the proportion of females, but not males, reporting adequate relief. Stool consistency, frequency and percentage days with urgency improved over placebo (P < 0.05) within the first month with all doses of alosetron, and persisted throughout the trial with all doses in female patients. With 1 mg b.d. alosetron, females had improved stool consistency and urgency within the first week, and adequate relief and improved stool frequency within the first 2 weeks. There was no consistent improvement in bowel function among male patients. Conclusion: In female irritable bower syndrome patients with predominant diarrhoea or alternating constipation and diarrhoea, alosetron is effective in treatment of abdominal pain and discomfort and bowel-related symptoms.
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U2 - 10.1046/j.1365-2036.1999.00610.x
DO - 10.1046/j.1365-2036.1999.00610.x
M3 - Article
C2 - 10468696
AN - SCOPUS:0032848856
SN - 0269-2813
VL - 13
SP - 1149
EP - 1159
JO - Alimentary Pharmacology and Therapeutics
JF - Alimentary Pharmacology and Therapeutics
IS - 9
ER -