Improved Noninvasive In Vivo Tracking of AAV-9 Gene Therapy Using the Perchlorate-Resistant Sodium Iodide Symporter from Minke Whale

Susanna C. Concilio, Lukkana Suksanpaisan, Linh Pham, Kah Whye Peng, Stephen J. Russell

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Uptake of radioisotopes by endogenous sodium iodide symporter (NIS) limits the efficacy and safety of NIS-mediated bioimaging and radionuclide therapy. Use of the naturally perchlorate-resistant NIS protein from minke whales and the NIS inhibitor perchlorate for in vivo imaging improves image clarity and reduces uptake in endogenous NIS-expressing tissues.

Original languageEnglish (US)
Pages (from-to)236-243
Number of pages8
JournalMolecular Therapy
Volume29
Issue number1
DOIs
StatePublished - Jan 6 2021

Keywords

  • AAV-9
  • NIS
  • PET
  • SLC5A5
  • SPECT
  • gene therapy
  • imaging
  • perchlorate
  • sodium iodide symporter

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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