@article{544385a4108a46e4a52fda6f6dadecdd,
title = "Improved Noninvasive In Vivo Tracking of AAV-9 Gene Therapy Using the Perchlorate-Resistant Sodium Iodide Symporter from Minke Whale",
abstract = "Uptake of radioisotopes by endogenous sodium iodide symporter (NIS) limits the efficacy and safety of NIS-mediated bioimaging and radionuclide therapy. Use of the naturally perchlorate-resistant NIS protein from minke whales and the NIS inhibitor perchlorate for in vivo imaging improves image clarity and reduces uptake in endogenous NIS-expressing tissues.",
keywords = "AAV-9, NIS, PET, SLC5A5, SPECT, gene therapy, imaging, perchlorate, sodium iodide symporter",
author = "Concilio, {Susanna C.} and Lukkana Suksanpaisan and Linh Pham and Peng, {Kah Whye} and Russell, {Stephen J.}",
note = "Funding Information: We thank Tracy Decklever and Cynthia Vernon with the Mayo Clinic Nuclear Imaging Facility for vital assistance with the animal imaging experiments. This study was supported by National Institutes of Health grants R44 TR001191 (to S.J.R.) and T32 AI132165 01A1 (to S.C.C.). Funding Information: We thank Tracy Decklever and Cynthia Vernon with the Mayo Clinic Nuclear Imaging Facility for vital assistance with the animal imaging experiments. This study was supported by National Institutes of Health grants R44 TR001191 (to S.J.R.) and T32 AI132165 01A1 (to S.C.C.). Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2021",
month = jan,
day = "6",
doi = "10.1016/j.ymthe.2020.09.036",
language = "English (US)",
volume = "29",
pages = "236--243",
journal = "Molecular Therapy",
issn = "1525-0016",
publisher = "Nature Publishing Group",
number = "1",
}