Introduction: Oxidative stress is a characteristic of exercise-induced asthma (EIA), however antioxidant supplementation may attenuate EIA. The purpose of this study was to determine if ascorbic (AsA) and α-tocopherol supplementation would improve airway function in subjects with EIA. Methods: A single-blind randomized crossover design with eight clinically diagnosed EIA subjects (22.0±0.7 year) and five healthy control subjects (28.2±1.4 year) was used. Subjects consumed vitamins (V) (AsA 500mg; α-tocopherol 300IU) or placebo (PLA) daily for three weeks, followed by a three week washout period and then three weeks of the alternative treatment. Ten-minute treadmill tests (90% VO2peak) were performed with pulmonary function testing (forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and between 25 and 75% (FEF25-75%), and peak expiratory flow rates (PEFR)) measured pre-exercise and 1, 5, 15, and 30min post-exercise. Results: Supplementation led to significant improvements at minute 5 and minute 15 in FVC; FEV1; PERF; FEF25-75% and minute 30 in FEV1 and FEF25-75% post-exercise. Conclusion: AsA and α-tocopherol may aid the recovery of pulmonary function in subjects with EIA.
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine