Abstract
The use of chlorotrityl resins for the immobilization of amines is sometimes deterred by the lengthy process of loading the reactants on the resins and product decomposition caused by the reactive chlorotrityl group in the presence of 1% TFA as a cleavage agent. Here, we report improved methods developed for selective and efficient loading of aminobenzoic acid derivatives on chlorotrityl resins and for cleavage of aniline-containing products from the resins without decomposition. These methods led to the synthesis of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors (FTIs) using IRORI's radio-frequency-encoded sorting technique and to the study of the applicability of the bivalence approach to the development of FTIs.
Original language | English (US) |
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Pages (from-to) | 407-413 |
Number of pages | 7 |
Journal | Journal of Combinatorial Chemistry |
Volume | 6 |
Issue number | 3 |
DOIs | |
State | Published - May 2004 |
ASJC Scopus subject areas
- General Chemistry