Improved accuracy of acute graft-versus-host disease staging among multiple centers

John E. Levine, William Hogan, Andrew C. Harris, Mark R Litzow, Yvonne A. Efebera, Steven M. Devine, Ran Reshef, James L M Ferrara

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The clinical staging of acute graft-versus-host disease (GVHD) varies significantly among bone marrow transplant (BMT) centers, but adherence to long-standing practices poses formidable barriers to standardization among centers. We have analyzed the sources of variability and developed a web-based remote data entry system that can be used by multiple centers simultaneously and that standardizes data collection in key areas. This user-friendly, intuitive interface resembles an online shopping site and eliminates error-prone entry of free text with drop-down menus and pop-up detailed guidance available at the point of data entry. Standardized documentation of symptoms and therapeutic response reduces errors in grade assignment and allows creation of confidence levels regarding the diagnosis. Early review and adjudication of borderline cases improves consistency of grading and further enhances consistency among centers. If this system achieves widespread use it may enhance the quality of data in multicenter trials to prevent and treat acute GVHD.

Original languageEnglish (US)
Pages (from-to)283-287
Number of pages5
JournalBest Practice and Research: Clinical Haematology
Volume27
Issue number3-4
DOIs
StatePublished - Sep 1 2014

Fingerprint

Graft vs Host Disease
Grafts
Data acquisition
Transplants
Information Systems
Documentation
Standardization
Multicenter Studies
Bone
Bone Marrow
Therapeutics
Data Accuracy

Keywords

  • BMT data entry system guidance graft-versus-host disease
  • bone marrow transplant
  • GVHD multiple centers online staging standardization web

ASJC Scopus subject areas

  • Oncology
  • Clinical Biochemistry
  • Medicine(all)

Cite this

Improved accuracy of acute graft-versus-host disease staging among multiple centers. / Levine, John E.; Hogan, William; Harris, Andrew C.; Litzow, Mark R; Efebera, Yvonne A.; Devine, Steven M.; Reshef, Ran; Ferrara, James L M.

In: Best Practice and Research: Clinical Haematology, Vol. 27, No. 3-4, 01.09.2014, p. 283-287.

Research output: Contribution to journalReview article

Levine, John E. ; Hogan, William ; Harris, Andrew C. ; Litzow, Mark R ; Efebera, Yvonne A. ; Devine, Steven M. ; Reshef, Ran ; Ferrara, James L M. / Improved accuracy of acute graft-versus-host disease staging among multiple centers. In: Best Practice and Research: Clinical Haematology. 2014 ; Vol. 27, No. 3-4. pp. 283-287.
@article{cce8c825626e497394159fa586efd052,
title = "Improved accuracy of acute graft-versus-host disease staging among multiple centers",
abstract = "The clinical staging of acute graft-versus-host disease (GVHD) varies significantly among bone marrow transplant (BMT) centers, but adherence to long-standing practices poses formidable barriers to standardization among centers. We have analyzed the sources of variability and developed a web-based remote data entry system that can be used by multiple centers simultaneously and that standardizes data collection in key areas. This user-friendly, intuitive interface resembles an online shopping site and eliminates error-prone entry of free text with drop-down menus and pop-up detailed guidance available at the point of data entry. Standardized documentation of symptoms and therapeutic response reduces errors in grade assignment and allows creation of confidence levels regarding the diagnosis. Early review and adjudication of borderline cases improves consistency of grading and further enhances consistency among centers. If this system achieves widespread use it may enhance the quality of data in multicenter trials to prevent and treat acute GVHD.",
keywords = "BMT data entry system guidance graft-versus-host disease, bone marrow transplant, GVHD multiple centers online staging standardization web",
author = "Levine, {John E.} and William Hogan and Harris, {Andrew C.} and Litzow, {Mark R} and Efebera, {Yvonne A.} and Devine, {Steven M.} and Ran Reshef and Ferrara, {James L M}",
year = "2014",
month = "9",
day = "1",
doi = "10.1016/j.beha.2014.10.011",
language = "English (US)",
volume = "27",
pages = "283--287",
journal = "Best Practice and Research in Clinical Haematology",
issn = "1521-6926",
publisher = "Bailliere Tindall Ltd",
number = "3-4",

}

TY - JOUR

T1 - Improved accuracy of acute graft-versus-host disease staging among multiple centers

AU - Levine, John E.

AU - Hogan, William

AU - Harris, Andrew C.

AU - Litzow, Mark R

AU - Efebera, Yvonne A.

AU - Devine, Steven M.

AU - Reshef, Ran

AU - Ferrara, James L M

PY - 2014/9/1

Y1 - 2014/9/1

N2 - The clinical staging of acute graft-versus-host disease (GVHD) varies significantly among bone marrow transplant (BMT) centers, but adherence to long-standing practices poses formidable barriers to standardization among centers. We have analyzed the sources of variability and developed a web-based remote data entry system that can be used by multiple centers simultaneously and that standardizes data collection in key areas. This user-friendly, intuitive interface resembles an online shopping site and eliminates error-prone entry of free text with drop-down menus and pop-up detailed guidance available at the point of data entry. Standardized documentation of symptoms and therapeutic response reduces errors in grade assignment and allows creation of confidence levels regarding the diagnosis. Early review and adjudication of borderline cases improves consistency of grading and further enhances consistency among centers. If this system achieves widespread use it may enhance the quality of data in multicenter trials to prevent and treat acute GVHD.

AB - The clinical staging of acute graft-versus-host disease (GVHD) varies significantly among bone marrow transplant (BMT) centers, but adherence to long-standing practices poses formidable barriers to standardization among centers. We have analyzed the sources of variability and developed a web-based remote data entry system that can be used by multiple centers simultaneously and that standardizes data collection in key areas. This user-friendly, intuitive interface resembles an online shopping site and eliminates error-prone entry of free text with drop-down menus and pop-up detailed guidance available at the point of data entry. Standardized documentation of symptoms and therapeutic response reduces errors in grade assignment and allows creation of confidence levels regarding the diagnosis. Early review and adjudication of borderline cases improves consistency of grading and further enhances consistency among centers. If this system achieves widespread use it may enhance the quality of data in multicenter trials to prevent and treat acute GVHD.

KW - BMT data entry system guidance graft-versus-host disease

KW - bone marrow transplant

KW - GVHD multiple centers online staging standardization web

UR - http://www.scopus.com/inward/record.url?scp=84923068583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923068583&partnerID=8YFLogxK

U2 - 10.1016/j.beha.2014.10.011

DO - 10.1016/j.beha.2014.10.011

M3 - Review article

C2 - 25455279

AN - SCOPUS:84923068583

VL - 27

SP - 283

EP - 287

JO - Best Practice and Research in Clinical Haematology

JF - Best Practice and Research in Clinical Haematology

SN - 1521-6926

IS - 3-4

ER -