Improved accuracy of acute graft-versus-host disease staging among multiple centers

John E. Levine; William J. Hogan; Andrew C. Harris; Mark R. Litzow; Yvonne A. Efebera; Steven M. Devine; Ran Reshef; James L.M. Ferrara

doi:10.1016/j.beha.2014.10.011

Improved accuracy of acute graft-versus-host disease staging among multiple centers

John E. Levine, William J. Hogan, Andrew C. Harris, Mark R. Litzow, Yvonne A. Efebera, Steven M. Devine, Ran Reshef, James L.M. Ferrara

Hematology

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

The clinical staging of acute graft-versus-host disease (GVHD) varies significantly among bone marrow transplant (BMT) centers, but adherence to long-standing practices poses formidable barriers to standardization among centers. We have analyzed the sources of variability and developed a web-based remote data entry system that can be used by multiple centers simultaneously and that standardizes data collection in key areas. This user-friendly, intuitive interface resembles an online shopping site and eliminates error-prone entry of free text with drop-down menus and pop-up detailed guidance available at the point of data entry. Standardized documentation of symptoms and therapeutic response reduces errors in grade assignment and allows creation of confidence levels regarding the diagnosis. Early review and adjudication of borderline cases improves consistency of grading and further enhances consistency among centers. If this system achieves widespread use it may enhance the quality of data in multicenter trials to prevent and treat acute GVHD.

Original language	English (US)
Pages (from-to)	283-287
Number of pages	5
Journal	Best Practice and Research: Clinical Haematology
Volume	27
Issue number	3-4
DOIs	https://doi.org/10.1016/j.beha.2014.10.011
State	Published - Sep 1 2014

Keywords

BMT data entry system guidance graft-versus-host disease
GVHD multiple centers online staging standardization web
bone marrow transplant

ASJC Scopus subject areas

Oncology
Clinical Biochemistry

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10.1016/j.beha.2014.10.011

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title = "Improved accuracy of acute graft-versus-host disease staging among multiple centers",

abstract = "The clinical staging of acute graft-versus-host disease (GVHD) varies significantly among bone marrow transplant (BMT) centers, but adherence to long-standing practices poses formidable barriers to standardization among centers. We have analyzed the sources of variability and developed a web-based remote data entry system that can be used by multiple centers simultaneously and that standardizes data collection in key areas. This user-friendly, intuitive interface resembles an online shopping site and eliminates error-prone entry of free text with drop-down menus and pop-up detailed guidance available at the point of data entry. Standardized documentation of symptoms and therapeutic response reduces errors in grade assignment and allows creation of confidence levels regarding the diagnosis. Early review and adjudication of borderline cases improves consistency of grading and further enhances consistency among centers. If this system achieves widespread use it may enhance the quality of data in multicenter trials to prevent and treat acute GVHD.",

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author = "Levine, {John E.} and Hogan, {William J.} and Harris, {Andrew C.} and Litzow, {Mark R.} and Efebera, {Yvonne A.} and Devine, {Steven M.} and Ran Reshef and Ferrara, {James L.M.}",

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doi = "10.1016/j.beha.2014.10.011",

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AU - Levine, John E.

AU - Hogan, William J.

AU - Harris, Andrew C.

AU - Litzow, Mark R.

AU - Efebera, Yvonne A.

AU - Devine, Steven M.

AU - Reshef, Ran

AU - Ferrara, James L.M.

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N2 - The clinical staging of acute graft-versus-host disease (GVHD) varies significantly among bone marrow transplant (BMT) centers, but adherence to long-standing practices poses formidable barriers to standardization among centers. We have analyzed the sources of variability and developed a web-based remote data entry system that can be used by multiple centers simultaneously and that standardizes data collection in key areas. This user-friendly, intuitive interface resembles an online shopping site and eliminates error-prone entry of free text with drop-down menus and pop-up detailed guidance available at the point of data entry. Standardized documentation of symptoms and therapeutic response reduces errors in grade assignment and allows creation of confidence levels regarding the diagnosis. Early review and adjudication of borderline cases improves consistency of grading and further enhances consistency among centers. If this system achieves widespread use it may enhance the quality of data in multicenter trials to prevent and treat acute GVHD.

AB - The clinical staging of acute graft-versus-host disease (GVHD) varies significantly among bone marrow transplant (BMT) centers, but adherence to long-standing practices poses formidable barriers to standardization among centers. We have analyzed the sources of variability and developed a web-based remote data entry system that can be used by multiple centers simultaneously and that standardizes data collection in key areas. This user-friendly, intuitive interface resembles an online shopping site and eliminates error-prone entry of free text with drop-down menus and pop-up detailed guidance available at the point of data entry. Standardized documentation of symptoms and therapeutic response reduces errors in grade assignment and allows creation of confidence levels regarding the diagnosis. Early review and adjudication of borderline cases improves consistency of grading and further enhances consistency among centers. If this system achieves widespread use it may enhance the quality of data in multicenter trials to prevent and treat acute GVHD.

KW - BMT data entry system guidance graft-versus-host disease

KW - GVHD multiple centers online staging standardization web

KW - bone marrow transplant

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ER -

Improved accuracy of acute graft-versus-host disease staging among multiple centers

Abstract

Keywords

ASJC Scopus subject areas

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