Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination

Jens Watzlawik, Arthur E. Warrington, Moses Rodriguez

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the CNS. A better understanding of why remyelination fails in MS is necessary to improve remyelination strategies. Remyelination is mediated by oligodendrocyte precursor cells (OPCs), which are widely distributed throughout the adult CNS. However, it is still unclear whether OPCs detectable in MS lesions survive the inflammatory response but are unable to myelinate or whether OPC and oligodendrocyte death is primarily responsible for remyelination failure and detectable OPCs enter demyelinated areas from adjacent tissue as the lesion evolves. Remyelination strategies should, therefore, focus on stimulation of differentiation or prevention of apoptosis, as well as establishment of a supportive environment for OPC-mediated remyelination, which may be especially important in chronically demyelinated lesions.

Original languageEnglish (US)
Pages (from-to)441-457
Number of pages17
JournalExpert review of neurotherapeutics
Volume10
Issue number3
DOIs
StatePublished - Mar 2010

Keywords

  • Apoptosis
  • Blood-brain barrier
  • Demyelination
  • Inflammation
  • Multiple sclerosis
  • Remyelination strategies

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

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