Importance of baseline mini-mental state examination as a prognostic factor for patients with low-grade glioma

Paul D. Brown; Jan C. Buckner; Judith R. O'Fallon; Nancy L. Iturria; Brian P. O'Neill; Cerise A. Brown; Bernd W. Scheithauer; Robert P. Dinapoli; Robert M. Arusell; Walter J. Curran; Ross Abrams; Edward G. Shaw

doi:10.1016/j.ijrobp.2003.10.040

Importance of baseline mini-mental state examination as a prognostic factor for patients with low-grade glioma

Paul D. Brown, Jan C. Buckner, Judith R. O'Fallon, Nancy L. Iturria, Brian P. O'Neill, Cerise A. Brown, Bernd W. Scheithauer, Robert P. Dinapoli, Robert M. Arusell, Walter J. Curran, Ross Abrams, Edward G. Shaw

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Purpose The outcome and cognitive performance data collected in a prospective, intergroup clinical trial were analyzed to assess the prognostic importance of the baseline (before radiotherapy) Mini-Mental State Examination (MMSE) score in patients with low-grade glioma. Methods and materials The patients studied were 203 adults with a supratentorial low-grade glioma randomly assigned to low-dose (50.4 Gy in 28 fractions) or high-dose (64.8 Gy in 36 fractions) localized radiotherapy. Folstein MMSE scores and neurologic function scores at baseline in combination with multiple other baseline variables were analyzed. The median follow-up was 7.4 years for the 101 patients still alive. Results Patients (n = 36) with an abnormal baseline MMSE score (≤26) had a worse 5-year progression-free survival rate (27% vs. 60%; p <0.001) and overall survival rate (31% vs. 76%; p <0.001) compared with those with a normal score. On multivariate analysis, the baseline MMSE score was a statistically significant predictor of survival. Other factors associated with overall survival were age, tumor size, and tumor histologic type. Conclusion The presence of an abnormal baseline MMSE score was a strong predictor of poorer progression-free and overall survival for patients with a low-grade glioma. The baseline MMSE should be considered in future prognostic scoring systems.

Original language	English (US)
Pages (from-to)	117-125
Number of pages	9
Journal	International Journal of Radiation Oncology Biology Physics
Volume	59
Issue number	1
DOIs	https://doi.org/10.1016/j.ijrobp.2003.10.040
State	Published - May 1 2004

Keywords

Glioma
Mini-Mental State Examination
Multivariate analysis
Prognosis
Radiotherapy

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/j.ijrobp.2003.10.040

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Brown, P. D., Buckner, J. C., O'Fallon, J. R., Iturria, N. L., O'Neill, B. P., Brown, C. A., Scheithauer, B. W., Dinapoli, R. P., Arusell, R. M., Curran, W. J., Abrams, R., & Shaw, E. G. (2004). Importance of baseline mini-mental state examination as a prognostic factor for patients with low-grade glioma. International Journal of Radiation Oncology Biology Physics, 59(1), 117-125. https://doi.org/10.1016/j.ijrobp.2003.10.040

Brown, PD, Buckner, JC, O'Fallon, JR, Iturria, NL, O'Neill, BP, Brown, CA, Scheithauer, BW, Dinapoli, RP, Arusell, RM, Curran, WJ, Abrams, R & Shaw, EG 2004, 'Importance of baseline mini-mental state examination as a prognostic factor for patients with low-grade glioma', International Journal of Radiation Oncology Biology Physics, vol. 59, no. 1, pp. 117-125. https://doi.org/10.1016/j.ijrobp.2003.10.040

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title = "Importance of baseline mini-mental state examination as a prognostic factor for patients with low-grade glioma",

abstract = "Purpose The outcome and cognitive performance data collected in a prospective, intergroup clinical trial were analyzed to assess the prognostic importance of the baseline (before radiotherapy) Mini-Mental State Examination (MMSE) score in patients with low-grade glioma. Methods and materials The patients studied were 203 adults with a supratentorial low-grade glioma randomly assigned to low-dose (50.4 Gy in 28 fractions) or high-dose (64.8 Gy in 36 fractions) localized radiotherapy. Folstein MMSE scores and neurologic function scores at baseline in combination with multiple other baseline variables were analyzed. The median follow-up was 7.4 years for the 101 patients still alive. Results Patients (n = 36) with an abnormal baseline MMSE score (≤26) had a worse 5-year progression-free survival rate (27% vs. 60%; p <0.001) and overall survival rate (31% vs. 76%; p <0.001) compared with those with a normal score. On multivariate analysis, the baseline MMSE score was a statistically significant predictor of survival. Other factors associated with overall survival were age, tumor size, and tumor histologic type. Conclusion The presence of an abnormal baseline MMSE score was a strong predictor of poorer progression-free and overall survival for patients with a low-grade glioma. The baseline MMSE should be considered in future prognostic scoring systems.",

keywords = "Glioma, Mini-Mental State Examination, Multivariate analysis, Prognosis, Radiotherapy",

author = "Brown, {Paul D.} and Buckner, {Jan C.} and O'Fallon, {Judith R.} and Iturria, {Nancy L.} and O'Neill, {Brian P.} and Brown, {Cerise A.} and Scheithauer, {Bernd W.} and Dinapoli, {Robert P.} and Arusell, {Robert M.} and Curran, {Walter J.} and Ross Abrams and Shaw, {Edward G.}",

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doi = "10.1016/j.ijrobp.2003.10.040",

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T1 - Importance of baseline mini-mental state examination as a prognostic factor for patients with low-grade glioma

AU - Brown, Paul D.

AU - Buckner, Jan C.

AU - O'Fallon, Judith R.

AU - Iturria, Nancy L.

AU - O'Neill, Brian P.

AU - Brown, Cerise A.

AU - Scheithauer, Bernd W.

AU - Dinapoli, Robert P.

AU - Arusell, Robert M.

AU - Curran, Walter J.

AU - Abrams, Ross

AU - Shaw, Edward G.

PY - 2004/5/1

Y1 - 2004/5/1

N2 - Purpose The outcome and cognitive performance data collected in a prospective, intergroup clinical trial were analyzed to assess the prognostic importance of the baseline (before radiotherapy) Mini-Mental State Examination (MMSE) score in patients with low-grade glioma. Methods and materials The patients studied were 203 adults with a supratentorial low-grade glioma randomly assigned to low-dose (50.4 Gy in 28 fractions) or high-dose (64.8 Gy in 36 fractions) localized radiotherapy. Folstein MMSE scores and neurologic function scores at baseline in combination with multiple other baseline variables were analyzed. The median follow-up was 7.4 years for the 101 patients still alive. Results Patients (n = 36) with an abnormal baseline MMSE score (≤26) had a worse 5-year progression-free survival rate (27% vs. 60%; p <0.001) and overall survival rate (31% vs. 76%; p <0.001) compared with those with a normal score. On multivariate analysis, the baseline MMSE score was a statistically significant predictor of survival. Other factors associated with overall survival were age, tumor size, and tumor histologic type. Conclusion The presence of an abnormal baseline MMSE score was a strong predictor of poorer progression-free and overall survival for patients with a low-grade glioma. The baseline MMSE should be considered in future prognostic scoring systems.

AB - Purpose The outcome and cognitive performance data collected in a prospective, intergroup clinical trial were analyzed to assess the prognostic importance of the baseline (before radiotherapy) Mini-Mental State Examination (MMSE) score in patients with low-grade glioma. Methods and materials The patients studied were 203 adults with a supratentorial low-grade glioma randomly assigned to low-dose (50.4 Gy in 28 fractions) or high-dose (64.8 Gy in 36 fractions) localized radiotherapy. Folstein MMSE scores and neurologic function scores at baseline in combination with multiple other baseline variables were analyzed. The median follow-up was 7.4 years for the 101 patients still alive. Results Patients (n = 36) with an abnormal baseline MMSE score (≤26) had a worse 5-year progression-free survival rate (27% vs. 60%; p <0.001) and overall survival rate (31% vs. 76%; p <0.001) compared with those with a normal score. On multivariate analysis, the baseline MMSE score was a statistically significant predictor of survival. Other factors associated with overall survival were age, tumor size, and tumor histologic type. Conclusion The presence of an abnormal baseline MMSE score was a strong predictor of poorer progression-free and overall survival for patients with a low-grade glioma. The baseline MMSE should be considered in future prognostic scoring systems.

KW - Glioma

KW - Mini-Mental State Examination

KW - Multivariate analysis

KW - Prognosis

KW - Radiotherapy

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Importance of baseline mini-mental state examination as a prognostic factor for patients with low-grade glioma

Abstract

Keywords

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