Abstract
Purpose The outcome and cognitive performance data collected in a prospective, intergroup clinical trial were analyzed to assess the prognostic importance of the baseline (before radiotherapy) Mini-Mental State Examination (MMSE) score in patients with low-grade glioma. Methods and materials The patients studied were 203 adults with a supratentorial low-grade glioma randomly assigned to low-dose (50.4 Gy in 28 fractions) or high-dose (64.8 Gy in 36 fractions) localized radiotherapy. Folstein MMSE scores and neurologic function scores at baseline in combination with multiple other baseline variables were analyzed. The median follow-up was 7.4 years for the 101 patients still alive. Results Patients (n = 36) with an abnormal baseline MMSE score (≤26) had a worse 5-year progression-free survival rate (27% vs. 60%; p <0.001) and overall survival rate (31% vs. 76%; p <0.001) compared with those with a normal score. On multivariate analysis, the baseline MMSE score was a statistically significant predictor of survival. Other factors associated with overall survival were age, tumor size, and tumor histologic type. Conclusion The presence of an abnormal baseline MMSE score was a strong predictor of poorer progression-free and overall survival for patients with a low-grade glioma. The baseline MMSE should be considered in future prognostic scoring systems.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-125 |
| Number of pages | 9 |
| Journal | International Journal of Radiation Oncology Biology Physics |
| Volume | 59 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 1 2004 |
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Keywords
- Glioma
- Mini-Mental State Examination
- Multivariate analysis
- Prognosis
- Radiotherapy
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Radiation
Cite this
Importance of baseline mini-mental state examination as a prognostic factor for patients with low-grade glioma. / Brown, Paul D.; Buckner, Jan Craig; O'Fallon, Judith R.; Iturria, Nancy L.; O'Neill, Brian Patrick; Brown, Cerise A.; Scheithauer, Bernd W.; Dinapoli, Robert P.; Arusell, Robert M.; Curran, Walter J.; Abrams, Ross; Shaw, Edward G.
In: International Journal of Radiation Oncology Biology Physics, Vol. 59, No. 1, 01.05.2004, p. 117-125.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Importance of baseline mini-mental state examination as a prognostic factor for patients with low-grade glioma
AU - Brown, Paul D.
AU - Buckner, Jan Craig
AU - O'Fallon, Judith R.
AU - Iturria, Nancy L.
AU - O'Neill, Brian Patrick
AU - Brown, Cerise A.
AU - Scheithauer, Bernd W.
AU - Dinapoli, Robert P.
AU - Arusell, Robert M.
AU - Curran, Walter J.
AU - Abrams, Ross
AU - Shaw, Edward G.
PY - 2004/5/1
Y1 - 2004/5/1
N2 - Purpose The outcome and cognitive performance data collected in a prospective, intergroup clinical trial were analyzed to assess the prognostic importance of the baseline (before radiotherapy) Mini-Mental State Examination (MMSE) score in patients with low-grade glioma. Methods and materials The patients studied were 203 adults with a supratentorial low-grade glioma randomly assigned to low-dose (50.4 Gy in 28 fractions) or high-dose (64.8 Gy in 36 fractions) localized radiotherapy. Folstein MMSE scores and neurologic function scores at baseline in combination with multiple other baseline variables were analyzed. The median follow-up was 7.4 years for the 101 patients still alive. Results Patients (n = 36) with an abnormal baseline MMSE score (≤26) had a worse 5-year progression-free survival rate (27% vs. 60%; p <0.001) and overall survival rate (31% vs. 76%; p <0.001) compared with those with a normal score. On multivariate analysis, the baseline MMSE score was a statistically significant predictor of survival. Other factors associated with overall survival were age, tumor size, and tumor histologic type. Conclusion The presence of an abnormal baseline MMSE score was a strong predictor of poorer progression-free and overall survival for patients with a low-grade glioma. The baseline MMSE should be considered in future prognostic scoring systems.
AB - Purpose The outcome and cognitive performance data collected in a prospective, intergroup clinical trial were analyzed to assess the prognostic importance of the baseline (before radiotherapy) Mini-Mental State Examination (MMSE) score in patients with low-grade glioma. Methods and materials The patients studied were 203 adults with a supratentorial low-grade glioma randomly assigned to low-dose (50.4 Gy in 28 fractions) or high-dose (64.8 Gy in 36 fractions) localized radiotherapy. Folstein MMSE scores and neurologic function scores at baseline in combination with multiple other baseline variables were analyzed. The median follow-up was 7.4 years for the 101 patients still alive. Results Patients (n = 36) with an abnormal baseline MMSE score (≤26) had a worse 5-year progression-free survival rate (27% vs. 60%; p <0.001) and overall survival rate (31% vs. 76%; p <0.001) compared with those with a normal score. On multivariate analysis, the baseline MMSE score was a statistically significant predictor of survival. Other factors associated with overall survival were age, tumor size, and tumor histologic type. Conclusion The presence of an abnormal baseline MMSE score was a strong predictor of poorer progression-free and overall survival for patients with a low-grade glioma. The baseline MMSE should be considered in future prognostic scoring systems.
KW - Glioma
KW - Mini-Mental State Examination
KW - Multivariate analysis
KW - Prognosis
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=16544385406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16544385406&partnerID=8YFLogxK
U2 - 10.1016/j.ijrobp.2003.10.040
DO - 10.1016/j.ijrobp.2003.10.040
M3 - Article
C2 - 15093907
AN - SCOPUS:16544385406
VL - 59
SP - 117
EP - 125
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
SN - 0360-3016
IS - 1
ER -