Implicit learning of sequential regularities and spatial contexts in corticobasal syndrome

Selam Negash, Bradley F Boeve, Yonas Endale Geda, Glenn E. Smith, David S Knopman, Robert J. Ivnik, Darlene V. Howard, James H. Howard, Ronald Carl Petersen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The present study investigated two forms of implicit learning in patients with corticobasal syndrome (CBS): contextual cueing and sequence learning. The former primarily implicates the medial temporal lobe system, and the latter, fronto-striatal-cerebellar circuits. Results revealed relatively preserved contextual cueing in patients with CBS. By contrast, sequence learning showed impairments, which seemed to reflect inability to execute correct responses in the presence of intact learning of the sequence. These findings provide the first characterization of implicit learning systems in CBS, and show that the two systems are differentially affected in patients with CBS.

Original languageEnglish (US)
Pages (from-to)133-143
Number of pages11
JournalNeurocase
Volume13
Issue number3
DOIs
StatePublished - Jun 2007

Fingerprint

Learning
Corpus Striatum
Temporal Lobe
Regularity
Implicit Learning
Syndrome
Sequence Learning
Contextual
Medial Temporal Lobe
Impairment
Learning Systems

Keywords

  • Corticobasal syndrome
  • Dementia
  • Implicit learning
  • Sequence learning
  • Spatial contexts

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Implicit learning of sequential regularities and spatial contexts in corticobasal syndrome. / Negash, Selam; Boeve, Bradley F; Geda, Yonas Endale; Smith, Glenn E.; Knopman, David S; Ivnik, Robert J.; Howard, Darlene V.; Howard, James H.; Petersen, Ronald Carl.

In: Neurocase, Vol. 13, No. 3, 06.2007, p. 133-143.

Research output: Contribution to journalArticle

Negash, Selam ; Boeve, Bradley F ; Geda, Yonas Endale ; Smith, Glenn E. ; Knopman, David S ; Ivnik, Robert J. ; Howard, Darlene V. ; Howard, James H. ; Petersen, Ronald Carl. / Implicit learning of sequential regularities and spatial contexts in corticobasal syndrome. In: Neurocase. 2007 ; Vol. 13, No. 3. pp. 133-143.
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