@article{0eae34629c5442f1a928d2ae8692cbd4,
title = "Implicit learning of sequential regularities and spatial contexts in corticobasal syndrome",
abstract = "The present study investigated two forms of implicit learning in patients with corticobasal syndrome (CBS): contextual cueing and sequence learning. The former primarily implicates the medial temporal lobe system, and the latter, fronto-striatal-cerebellar circuits. Results revealed relatively preserved contextual cueing in patients with CBS. By contrast, sequence learning showed impairments, which seemed to reflect inability to execute correct responses in the presence of intact learning of the sequence. These findings provide the first characterization of implicit learning systems in CBS, and show that the two systems are differentially affected in patients with CBS.",
keywords = "Corticobasal syndrome, Dementia, Implicit learning, Sequence learning, Spatial contexts",
author = "Selam Negash and Boeve, {Bradley F.} and Geda, {Yonas E.} and Smith, {Glenn E.} and Knopman, {David S.} and Ivnik, {Robert J.} and Howard, {Darlene V.} and Howard, {James H.} and Petersen, {Ronald C.}",
note = "Funding Information: This work was supported by grants P50 AG16574, U01 AG06786, R37 AG15450, K01 MH 68351, and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer{\textquoteright}s Disease Research Program of the Mayo Foundation, and by Postdoctoral Diversity Program in Neuroscience Fellowship from the American Psychological Association. We are indebted to our colleagues with whom we work on corticobasal syndrome and corticobasal degeneration research, namely Keith A. Josephs, M.D., Daniel A. Drubach, M.D., Josephs Y. Matsumoto, M.D., J. Eric Ahlskog, Ph.D, M.D., Joseph E. Parisi, M.D., and Dennis W. Dickson, M.D. We thank our staff in the Mayo Alzheimer{\textquoteright}s Disease Research Center for their evaluation and education/counseling for many of the patients and families included in this report. We particularly extend our gratitude to the patients and their families for participating in research on neurodegenerative disease.",
year = "2007",
month = jun,
doi = "10.1080/13554790701401852",
language = "English (US)",
volume = "13",
pages = "133--143",
journal = "Neurocase",
issn = "1355-4794",
publisher = "Psychology Press Ltd",
number = "3",
}