Implications of pharmacogenomics for anesthesia providers

Tori Ama, Sou Bounmythavong, Jodee Blaze, Melissa Weismann, Mary Shirk Marienau, Wayne T. Nicholson

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

The practice of anesthesia has long been considered an art and a science, with interpatient variability in drug response being the rule, rather than the exception. Pharmacogenomics, which studies the role of genetics in drug response, is emerging as a discipline that may impact anesthetic management. The purpose of this review is to provide clinicians with basic knowledge related to pharmacogenomics and its implications in anesthesia. This review focuses on pharmacogenomics related to commonly used drugs in anesthesia. Pharmacogenomics as a predictor of drug response is increasingly used in medicine and drug development. By expanding the knowledge base of anesthesia providers, pharmacogenomic considerations have the potential to improve therapeutic outcomes and individualize drug therapy, while avoiding toxic effects and treatment failure. However, because pharmacogenomics may not fully explain variability in drug response, implementation should be in conjunction with traditional anesthesia considerations.

Original languageEnglish (US)
Pages (from-to)393-399
Number of pages7
JournalAANA Journal
Volume78
Issue number5
StatePublished - Oct 1 2010

Keywords

  • Anesthesia
  • Drug variability
  • Pharmacogenetics
  • Pharmacogenomics
  • Polymorphisms

ASJC Scopus subject areas

  • Medical–Surgical
  • Advanced and Specialized Nursing
  • Anesthesiology and Pain Medicine

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