Implications of irradiating the subventricular zone stem cell niche

Vivian Capilla-Gonzalez, Janice M. Bonsu, Kristin J. Redmond, Jose Manuel Garcia-Verdugo, Alfredo Quinones-Hinojosa

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Radiation therapy is a standard treatment for brain tumor patients. However, it comes with side effects, such as neurological deficits. While likely multi-factorial, the effect may in part be associated with the impact of radiation on the neurogenic niches. In the adult mammalian brain, the neurogenic niches are localized in the subventricular zone (SVZ) of the lateral ventricles and the dentate gyrus of the hippocampus, where the neural stem cells (NSCs) reside. Several reports showed that radiation produces a drastic decrease in the proliferative capacity of these regions, which is related to functional decline. In particular, radiation to the SVZ led to a reduced long-term olfactory memory and a reduced capacity to respond to brain damage in animal models, as well as compromised tumor outcomes in patients. By contrast, other studies in humans suggested that increased radiation dose to the SVZ may be associated with longer progression-free survival in patients with high-grade glioma. In this review, we summarize the cellular and functional effects of irradiating the SVZ niche. In particular, we review the pros and cons of using radiation during brain tumor treatment, discussing the complex relationship between radiation dose to the SVZ and both tumor control and toxicity.

Original languageEnglish (US)
Pages (from-to)387-396
Number of pages10
JournalStem Cell Research
Volume16
Issue number2
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Fingerprint

Stem Cell Niche
Lateral Ventricles
Radiation
Brain Neoplasms
Parahippocampal Gyrus
Neural Stem Cells
Long-Term Memory
Dentate Gyrus
Brain
Glioma
Disease-Free Survival
Neoplasms
Radiotherapy
Animal Models
Therapeutics

Keywords

  • Brain tumor
  • Neural stem cells
  • Neurogenesis
  • Radiation
  • Subventricular zone

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Medicine(all)

Cite this

Capilla-Gonzalez, V., Bonsu, J. M., Redmond, K. J., Garcia-Verdugo, J. M., & Quinones-Hinojosa, A. (2016). Implications of irradiating the subventricular zone stem cell niche. Stem Cell Research, 16(2), 387-396. https://doi.org/10.1016/j.scr.2016.02.031

Implications of irradiating the subventricular zone stem cell niche. / Capilla-Gonzalez, Vivian; Bonsu, Janice M.; Redmond, Kristin J.; Garcia-Verdugo, Jose Manuel; Quinones-Hinojosa, Alfredo.

In: Stem Cell Research, Vol. 16, No. 2, 01.03.2016, p. 387-396.

Research output: Contribution to journalReview article

Capilla-Gonzalez, V, Bonsu, JM, Redmond, KJ, Garcia-Verdugo, JM & Quinones-Hinojosa, A 2016, 'Implications of irradiating the subventricular zone stem cell niche', Stem Cell Research, vol. 16, no. 2, pp. 387-396. https://doi.org/10.1016/j.scr.2016.02.031
Capilla-Gonzalez, Vivian ; Bonsu, Janice M. ; Redmond, Kristin J. ; Garcia-Verdugo, Jose Manuel ; Quinones-Hinojosa, Alfredo. / Implications of irradiating the subventricular zone stem cell niche. In: Stem Cell Research. 2016 ; Vol. 16, No. 2. pp. 387-396.
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