Implications of heterogeneous bead behavior on cell mechanical properties measured with magnetic twisting cytometry

Ben Fabry, Geoffrey N. Maksym, Rolf D. Hubmayr, James P. Butler, Jeffrey J. Fredberg

Research output: Contribution to journalConference article

68 Scopus citations

Abstract

Magnetic twisting cytometry (MTC) measures cellular mechanical properties, such as cell stiffness and viscosity, by applying mechanical stress to specific cell surface receptors via ligand-coated ferromagnetic beads. MTC measures simultaneously the rotation of approximately 50,000 beads attached to 20,000-40,000 cells. Here we show direct evidence of heterogeneous bead behavior and examine its consequences in the interpretation of cell mechanical properties.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Volume194
Issue number1
DOIs
StatePublished - Apr 1999
EventProceedings of 1998 2nd International Conference on Scientific and Clinical Applications of Magnetic Carriers - Cleveland, OH, USA
Duration: May 28 1998May 30 1998

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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