Implications of heterogeneous bead behavior on cell mechanical properties measured with magnetic twisting cytometry

Ben Fabry, Geoffrey N. Maksym, Rolf D. Hubmayr, James P. Butler, Jeffrey J. Fredberg

Research output: Contribution to journalConference articlepeer-review

70 Scopus citations

Abstract

Magnetic twisting cytometry (MTC) measures cellular mechanical properties, such as cell stiffness and viscosity, by applying mechanical stress to specific cell surface receptors via ligand-coated ferromagnetic beads. MTC measures simultaneously the rotation of approximately 50,000 beads attached to 20,000-40,000 cells. Here we show direct evidence of heterogeneous bead behavior and examine its consequences in the interpretation of cell mechanical properties.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Volume194
Issue number1
DOIs
StatePublished - Apr 1999
EventProceedings of 1998 2nd International Conference on Scientific and Clinical Applications of Magnetic Carriers - Cleveland, OH, USA
Duration: May 28 1998May 30 1998

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Implications of heterogeneous bead behavior on cell mechanical properties measured with magnetic twisting cytometry'. Together they form a unique fingerprint.

Cite this