Implications of heterogeneous bead behavior on cell mechanical properties measured with magnetic twisting cytometry

Ben Fabry, Geoffrey N. Maksym, Rolf D. Hubmayr, James P. Butler, Jeffrey J. Fredberg

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Magnetic twisting cytometry (MTC) measures cellular mechanical properties, such as cell stiffness and viscosity, by applying mechanical stress to specific cell surface receptors via ligand-coated ferromagnetic beads. MTC measures simultaneously the rotation of approximately 50,000 beads attached to 20,000-40,000 cells. Here we show direct evidence of heterogeneous bead behavior and examine its consequences in the interpretation of cell mechanical properties.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Volume194
Issue number1
DOIs
StatePublished - Apr 1999

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cytometry
twisting
beads
mechanical properties
Mechanical properties
Cell Surface Receptors
cells
Ligands
Stiffness
Viscosity
stiffness
viscosity
ligands

ASJC Scopus subject areas

  • Condensed Matter Physics

Cite this

Implications of heterogeneous bead behavior on cell mechanical properties measured with magnetic twisting cytometry. / Fabry, Ben; Maksym, Geoffrey N.; Hubmayr, Rolf D.; Butler, James P.; Fredberg, Jeffrey J.

In: Journal of Magnetism and Magnetic Materials, Vol. 194, No. 1, 04.1999, p. 120-125.

Research output: Contribution to journalArticle

Fabry, Ben ; Maksym, Geoffrey N. ; Hubmayr, Rolf D. ; Butler, James P. ; Fredberg, Jeffrey J. / Implications of heterogeneous bead behavior on cell mechanical properties measured with magnetic twisting cytometry. In: Journal of Magnetism and Magnetic Materials. 1999 ; Vol. 194, No. 1. pp. 120-125.
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