Implications of detecting serum monoclonal protein by MASS-fix following stem cell transplantation in multiple myeloma

Jithma P. Abeykoon; David L. Murray; Isaiah Murray; Dragan Jevremovic; Gregory E. Otteson; Angela Dispenzieri; Bonnie K. Arendt; Surendra Dasari; Morie Gertz; Wilson I. Gonsalves; Taxiarchis V. Kourelis; Eli Muchtar; David Dingli; Rahma Warsame; Ronald S. Go; Martha Q. Lacy; Nelson Leung; Francis Buadi; Yi Lin; Robert A. Kyle; Vincent Rajkumar; Shaji Kumar; Prashant Kapoor

doi:10.1111/bjh.17195

Implications of detecting serum monoclonal protein by MASS-fix following stem cell transplantation in multiple myeloma

Jithma P. Abeykoon, David L. Murray, Isaiah Murray, Dragan Jevremovic, Gregory E. Otteson, Angela Dispenzieri, Bonnie K. Arendt, Surendra Dasari, Morie Gertz, Wilson I. Gonsalves, Taxiarchis V. Kourelis, Eli Muchtar, David Dingli, Rahma Warsame, Ronald S. Go, Martha Q. Lacy, Nelson Leung, Francis Buadi, Yi Lin, Robert A. KyleVincent Rajkumar, Shaji Kumar, Prashant Kapoor

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Measurable residual disease (MRD) assessment by marrow-based next-generation flow cytometry (NGF) following autologous stem cell transplantation (ASCT) may lead to false-negative results due to patchy marrow involvement and extramedullary disease in patients with multiple myeloma. We assessed the value of simultaneous MRD evaluation with NGF and serum matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MASS-FIX). Of all 61 complete responders who were NGF-negative for MRD, around day-100 post ASCT, 59% were MASS-FIX-positive. At median follow-up of 26 months, 69% of MASS-FIX(+)/NGF(−) patients were alive and progression-free versus 96% of MASS-FIX(-)/NGF(−) patients, P = 0·02. MASS-FIX, a simple peripheral blood-based assay complements marrow-based NGF to accurately prognosticate patients with myeloma.

Original language	English (US)
Pages (from-to)	380-385
Number of pages	6
Journal	British journal of haematology
Volume	193
Issue number	2
DOIs	https://doi.org/10.1111/bjh.17195
State	Published - Apr 2021

Keywords

mass spectroscopy
measurable residual disease
prognosis

ASJC Scopus subject areas

Hematology

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10.1111/bjh.17195

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Abeykoon, J. P., Murray, D. L., Murray, I., Jevremovic, D., Otteson, G. E., Dispenzieri, A., Arendt, B. K., Dasari, S., Gertz, M., Gonsalves, W. I., Kourelis, T. V., Muchtar, E., Dingli, D., Warsame, R., Go, R. S., Lacy, M. Q., Leung, N., Buadi, F., Lin, Y., ... Kapoor, P. (2021). Implications of detecting serum monoclonal protein by MASS-fix following stem cell transplantation in multiple myeloma. British journal of haematology, 193(2), 380-385. https://doi.org/10.1111/bjh.17195

Abeykoon, JP, Murray, DL, Murray, I, Jevremovic, D, Otteson, GE, Dispenzieri, A, Arendt, BK, Dasari, S , Gertz, M , Gonsalves, WI , Kourelis, TV, Muchtar, E, Dingli, D, Warsame, R, Go, RS, Lacy, MQ, Leung, N, Buadi, F, Lin, Y, Kyle, RA, Rajkumar, V , Kumar, S & Kapoor, P 2021, 'Implications of detecting serum monoclonal protein by MASS-fix following stem cell transplantation in multiple myeloma', British journal of haematology, vol. 193, no. 2, pp. 380-385. https://doi.org/10.1111/bjh.17195

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title = "Implications of detecting serum monoclonal protein by MASS-fix following stem cell transplantation in multiple myeloma",

abstract = "Measurable residual disease (MRD) assessment by marrow-based next-generation flow cytometry (NGF) following autologous stem cell transplantation (ASCT) may lead to false-negative results due to patchy marrow involvement and extramedullary disease in patients with multiple myeloma. We assessed the value of simultaneous MRD evaluation with NGF and serum matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MASS-FIX). Of all 61 complete responders who were NGF-negative for MRD, around day-100 post ASCT, 59% were MASS-FIX-positive. At median follow-up of 26 months, 69% of MASS-FIX(+)/NGF(−) patients were alive and progression-free versus 96% of MASS-FIX(-)/NGF(−) patients, P = 0·02. MASS-FIX, a simple peripheral blood-based assay complements marrow-based NGF to accurately prognosticate patients with myeloma.",

keywords = "mass spectroscopy, measurable residual disease, prognosis",

author = "Abeykoon, {Jithma P.} and Murray, {David L.} and Isaiah Murray and Dragan Jevremovic and Otteson, {Gregory E.} and Angela Dispenzieri and Arendt, {Bonnie K.} and Surendra Dasari and Morie Gertz and Gonsalves, {Wilson I.} and Kourelis, {Taxiarchis V.} and Eli Muchtar and David Dingli and Rahma Warsame and Go, {Ronald S.} and Lacy, {Martha Q.} and Nelson Leung and Francis Buadi and Yi Lin and Kyle, {Robert A.} and Vincent Rajkumar and Shaji Kumar and Prashant Kapoor",

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doi = "10.1111/bjh.17195",

language = "English (US)",

volume = "193",

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AU - Abeykoon, Jithma P.

AU - Murray, David L.

AU - Murray, Isaiah

AU - Jevremovic, Dragan

AU - Otteson, Gregory E.

AU - Dispenzieri, Angela

AU - Arendt, Bonnie K.

AU - Dasari, Surendra

AU - Gertz, Morie

AU - Gonsalves, Wilson I.

AU - Kourelis, Taxiarchis V.

AU - Muchtar, Eli

AU - Dingli, David

AU - Warsame, Rahma

AU - Go, Ronald S.

AU - Lacy, Martha Q.

AU - Leung, Nelson

AU - Buadi, Francis

AU - Lin, Yi

AU - Kyle, Robert A.

AU - Rajkumar, Vincent

AU - Kumar, Shaji

AU - Kapoor, Prashant

PY - 2021/4

Y1 - 2021/4

N2 - Measurable residual disease (MRD) assessment by marrow-based next-generation flow cytometry (NGF) following autologous stem cell transplantation (ASCT) may lead to false-negative results due to patchy marrow involvement and extramedullary disease in patients with multiple myeloma. We assessed the value of simultaneous MRD evaluation with NGF and serum matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MASS-FIX). Of all 61 complete responders who were NGF-negative for MRD, around day-100 post ASCT, 59% were MASS-FIX-positive. At median follow-up of 26 months, 69% of MASS-FIX(+)/NGF(−) patients were alive and progression-free versus 96% of MASS-FIX(-)/NGF(−) patients, P = 0·02. MASS-FIX, a simple peripheral blood-based assay complements marrow-based NGF to accurately prognosticate patients with myeloma.

AB - Measurable residual disease (MRD) assessment by marrow-based next-generation flow cytometry (NGF) following autologous stem cell transplantation (ASCT) may lead to false-negative results due to patchy marrow involvement and extramedullary disease in patients with multiple myeloma. We assessed the value of simultaneous MRD evaluation with NGF and serum matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MASS-FIX). Of all 61 complete responders who were NGF-negative for MRD, around day-100 post ASCT, 59% were MASS-FIX-positive. At median follow-up of 26 months, 69% of MASS-FIX(+)/NGF(−) patients were alive and progression-free versus 96% of MASS-FIX(-)/NGF(−) patients, P = 0·02. MASS-FIX, a simple peripheral blood-based assay complements marrow-based NGF to accurately prognosticate patients with myeloma.

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Implications of detecting serum monoclonal protein by MASS-fix following stem cell transplantation in multiple myeloma

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Keywords

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