TY - JOUR
T1 - Implications for tumor microenvironment and epithelial crosstalk in the management of gastrointestinal cancers
AU - Ge, Yang
AU - Westphalen, C. Benedikt
AU - Ma, Wen Wee
AU - Vega, Kenneth J.
AU - Weygant, Nathaniel
N1 - Publisher Copyright:
© 2019 Yang Ge et al.This is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
PY - 2019
Y1 - 2019
N2 - Rapid advances in technology are revealing previously unknown organization, cooperation, and limitations within the population of nontumor cells surrounding the tumor epithelium known as the tumor microenvironment (TME). Nowhere are these findings more pertinent than in the gastrointestinal (GI) tract where exquisite cell specialization supports a complex microenvironmental niche characterized by rapid stemness-associated cell turnover, pathogen sensing, epithelial orchestration of immune signaling, and other facets that maintain the complex balance between homeostasis, inflammation, and disease. Here, we summarize and discuss select emerging concepts in the precancerous microenvironment, TME, and tumor epithelial-TME crosstalk as well as their implications for the management of GI cancers.
AB - Rapid advances in technology are revealing previously unknown organization, cooperation, and limitations within the population of nontumor cells surrounding the tumor epithelium known as the tumor microenvironment (TME). Nowhere are these findings more pertinent than in the gastrointestinal (GI) tract where exquisite cell specialization supports a complex microenvironmental niche characterized by rapid stemness-associated cell turnover, pathogen sensing, epithelial orchestration of immune signaling, and other facets that maintain the complex balance between homeostasis, inflammation, and disease. Here, we summarize and discuss select emerging concepts in the precancerous microenvironment, TME, and tumor epithelial-TME crosstalk as well as their implications for the management of GI cancers.
UR - http://www.scopus.com/inward/record.url?scp=85074933048&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074933048&partnerID=8YFLogxK
U2 - 10.1155/2019/4835318
DO - 10.1155/2019/4835318
M3 - Review article
AN - SCOPUS:85074933048
SN - 1687-8450
VL - 2019
JO - Journal of Oncology
JF - Journal of Oncology
M1 - 4835318
ER -