Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions

G. S. Stein, Andre J van Wijnen, J. L. Stein, J. B. Lian, S. H. Pockwinse, S. McNeil

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Components of nuclear architecture are functionally interrelated with control of gene expression. There is growing appreciation that multiple levels of nuclear organization integrate the regulatory cues that support activation and suppression of genes as well as the processing of gene transcripts. The linear representation of genes and promoter elements provide the potential for responsiveness to physiological regulatory signals. Parameters of chromatin structure and nucleosome organization support synergism between activities at independent regulatory sequences and render promoter elements accessible or refractory to transcription factors. Association of genes, transcription factors, and the machinery for transcript processing with the nuclear matrix facilitates fidelity of gene expression within the three-dimensional context of nuclear architecture. Mechanisms must be defined that couple nuclear morphology with enzymatic parameters of gene expression. The recent characterization of factors that mediate chromatin remodeling and identification of intranuclear targeting signals that direct transcription factors to subnuclear domains where gene expression occurs link genetic and structural components of transcriptional control. Nuclear reorganization and aberrant intranuclear trafficking of transcription factors for developmental and tissue-specific control occurs in tumor cells and in neurological disorders. Compromises in nuclear structure-function interrelationships can occur as a consequence of microgravity-mediated perturbations in cellular architecture.

Original languageEnglish (US)
JournalFASEB Journal
Volume13
Issue number8 SUPPL.
StatePublished - 1999
Externally publishedYes

Fingerprint

microgravity
Weightlessness
Microgravity
Gene expression
Transcription Factors
transcription factors
Genes
Gene Expression
gene expression
Chromatin
chromatin
genes
promoter regions
Organizations
nuclear matrix
Nuclear Matrix
regulatory sequences
nucleosomes
Chromatin Assembly and Disassembly
nervous system diseases

Keywords

  • Chromatin
  • Nuclear matrix
  • Nucleosomes
  • Transcription

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., Pockwinse, S. H., & McNeil, S. (1999). Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions. FASEB Journal, 13(8 SUPPL.).

Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions. / Stein, G. S.; van Wijnen, Andre J; Stein, J. L.; Lian, J. B.; Pockwinse, S. H.; McNeil, S.

In: FASEB Journal, Vol. 13, No. 8 SUPPL., 1999.

Research output: Contribution to journalArticle

Stein, GS, van Wijnen, AJ, Stein, JL, Lian, JB, Pockwinse, SH & McNeil, S 1999, 'Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions', FASEB Journal, vol. 13, no. 8 SUPPL..
Stein, G. S. ; van Wijnen, Andre J ; Stein, J. L. ; Lian, J. B. ; Pockwinse, S. H. ; McNeil, S. / Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions. In: FASEB Journal. 1999 ; Vol. 13, No. 8 SUPPL.
@article{44651817920a49db957f2ed02f836aad,
title = "Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions",
abstract = "Components of nuclear architecture are functionally interrelated with control of gene expression. There is growing appreciation that multiple levels of nuclear organization integrate the regulatory cues that support activation and suppression of genes as well as the processing of gene transcripts. The linear representation of genes and promoter elements provide the potential for responsiveness to physiological regulatory signals. Parameters of chromatin structure and nucleosome organization support synergism between activities at independent regulatory sequences and render promoter elements accessible or refractory to transcription factors. Association of genes, transcription factors, and the machinery for transcript processing with the nuclear matrix facilitates fidelity of gene expression within the three-dimensional context of nuclear architecture. Mechanisms must be defined that couple nuclear morphology with enzymatic parameters of gene expression. The recent characterization of factors that mediate chromatin remodeling and identification of intranuclear targeting signals that direct transcription factors to subnuclear domains where gene expression occurs link genetic and structural components of transcriptional control. Nuclear reorganization and aberrant intranuclear trafficking of transcription factors for developmental and tissue-specific control occurs in tumor cells and in neurological disorders. Compromises in nuclear structure-function interrelationships can occur as a consequence of microgravity-mediated perturbations in cellular architecture.",
keywords = "Chromatin, Nuclear matrix, Nucleosomes, Transcription",
author = "Stein, {G. S.} and {van Wijnen}, {Andre J} and Stein, {J. L.} and Lian, {J. B.} and Pockwinse, {S. H.} and S. McNeil",
year = "1999",
language = "English (US)",
volume = "13",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "8 SUPPL.",

}

TY - JOUR

T1 - Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions

AU - Stein, G. S.

AU - van Wijnen, Andre J

AU - Stein, J. L.

AU - Lian, J. B.

AU - Pockwinse, S. H.

AU - McNeil, S.

PY - 1999

Y1 - 1999

N2 - Components of nuclear architecture are functionally interrelated with control of gene expression. There is growing appreciation that multiple levels of nuclear organization integrate the regulatory cues that support activation and suppression of genes as well as the processing of gene transcripts. The linear representation of genes and promoter elements provide the potential for responsiveness to physiological regulatory signals. Parameters of chromatin structure and nucleosome organization support synergism between activities at independent regulatory sequences and render promoter elements accessible or refractory to transcription factors. Association of genes, transcription factors, and the machinery for transcript processing with the nuclear matrix facilitates fidelity of gene expression within the three-dimensional context of nuclear architecture. Mechanisms must be defined that couple nuclear morphology with enzymatic parameters of gene expression. The recent characterization of factors that mediate chromatin remodeling and identification of intranuclear targeting signals that direct transcription factors to subnuclear domains where gene expression occurs link genetic and structural components of transcriptional control. Nuclear reorganization and aberrant intranuclear trafficking of transcription factors for developmental and tissue-specific control occurs in tumor cells and in neurological disorders. Compromises in nuclear structure-function interrelationships can occur as a consequence of microgravity-mediated perturbations in cellular architecture.

AB - Components of nuclear architecture are functionally interrelated with control of gene expression. There is growing appreciation that multiple levels of nuclear organization integrate the regulatory cues that support activation and suppression of genes as well as the processing of gene transcripts. The linear representation of genes and promoter elements provide the potential for responsiveness to physiological regulatory signals. Parameters of chromatin structure and nucleosome organization support synergism between activities at independent regulatory sequences and render promoter elements accessible or refractory to transcription factors. Association of genes, transcription factors, and the machinery for transcript processing with the nuclear matrix facilitates fidelity of gene expression within the three-dimensional context of nuclear architecture. Mechanisms must be defined that couple nuclear morphology with enzymatic parameters of gene expression. The recent characterization of factors that mediate chromatin remodeling and identification of intranuclear targeting signals that direct transcription factors to subnuclear domains where gene expression occurs link genetic and structural components of transcriptional control. Nuclear reorganization and aberrant intranuclear trafficking of transcription factors for developmental and tissue-specific control occurs in tumor cells and in neurological disorders. Compromises in nuclear structure-function interrelationships can occur as a consequence of microgravity-mediated perturbations in cellular architecture.

KW - Chromatin

KW - Nuclear matrix

KW - Nucleosomes

KW - Transcription

UR - http://www.scopus.com/inward/record.url?scp=0032895851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032895851&partnerID=8YFLogxK

M3 - Article

C2 - 10352158

AN - SCOPUS:0032895851

VL - 13

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 8 SUPPL.

ER -