TY - JOUR
T1 - Implementing individualized medicine into the medical practice
AU - Lazaridis, Konstantinos N.
AU - MCAllister, Tammy M.
AU - Babovic-Vuksanovic, Dusica
AU - Beck, Scott A.
AU - Borad, Mitesh J.
AU - Bryce, Alan H.
AU - Chanan-Khan, Asher A.
AU - Ferber, Matthew J.
AU - Fonseca, Rafael
AU - Johnson, Kiley J.
AU - Klee, Eric W.
AU - Lindor, Noralane M.
AU - MCCormick, Jennifer B.
AU - MCWilliams, Robert R.
AU - Parker, Alexander S.
AU - Riegert-Johnson, Douglas L.
AU - Rohrer Vitek, Carolyn R.
AU - Schahl, Kimberly A.
AU - Schultz, Cloann
AU - Stewart, Keith
AU - Then, George C.
AU - Wieben, Eric D.
AU - Farrugia, Gianrico
PY - 2014/3
Y1 - 2014/3
N2 - There is increasing recognition that genomic medicine as part of individualized medicine has a defined role in patient care. Rapid advances in technology and decreasing cost combine to bring genomic medicine closer to the clinical practice. There is also growing evidence that genomic-based medicine can advance patient outcomes, tailor therapy and decrease side effects. However the challenges to integrate genomics into the workflow involved in patient care remain vast, stalling assimilation of genomic medicine into mainstream medical practice. In this review we describe the approach taken by one institution to further individualize medicine by offering, executing and interpreting whole exome sequencing on a clinical basis through an enterprise-wide, standalone individualized medicine clinic. We present our experience designing and executing such an individualized medicine clinic, sharing lessons learned and describing early implementation outcomes.
AB - There is increasing recognition that genomic medicine as part of individualized medicine has a defined role in patient care. Rapid advances in technology and decreasing cost combine to bring genomic medicine closer to the clinical practice. There is also growing evidence that genomic-based medicine can advance patient outcomes, tailor therapy and decrease side effects. However the challenges to integrate genomics into the workflow involved in patient care remain vast, stalling assimilation of genomic medicine into mainstream medical practice. In this review we describe the approach taken by one institution to further individualize medicine by offering, executing and interpreting whole exome sequencing on a clinical basis through an enterprise-wide, standalone individualized medicine clinic. We present our experience designing and executing such an individualized medicine clinic, sharing lessons learned and describing early implementation outcomes.
KW - Genomic medicine
KW - Individualized medicine clinic
KW - Personalized medicine
KW - Whole exome sequencing
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U2 - 10.1002/ajmg.c.31387
DO - 10.1002/ajmg.c.31387
M3 - Article
C2 - 24616301
AN - SCOPUS:84896317365
SN - 1552-4868
VL - 166
SP - 15
EP - 23
JO - American Journal of Medical Genetics, Part C: Seminars in Medical Genetics
JF - American Journal of Medical Genetics, Part C: Seminars in Medical Genetics
IS - 1
ER -