Implementing individualized medicine into the medical practice

Konstantinos N Lazaridis, Tammy M. MCAllister, Dusica Babovic-Vuksanovic, Scott A. Beck, Mitesh J Borad, Alan H Bryce, Asher A Chanan Khan, Matthew J. Ferber, Rafael Fonseca, Kiley J. Johnson, Eric W Klee, Noralane Morey Lindor, Jennifer B. MCCormick, Robert R Mc Williams, Alexander Parker, Douglas L. Riegert-Johnson, Carolyn R. Rohrer Vitek, Kimberly A. Schahl, Cloann Schultz, Alexander Keith StewartGeorge C. Then, Eric D Wieben, Gianrico Farrugia

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

There is increasing recognition that genomic medicine as part of individualized medicine has a defined role in patient care. Rapid advances in technology and decreasing cost combine to bring genomic medicine closer to the clinical practice. There is also growing evidence that genomic-based medicine can advance patient outcomes, tailor therapy and decrease side effects. However the challenges to integrate genomics into the workflow involved in patient care remain vast, stalling assimilation of genomic medicine into mainstream medical practice. In this review we describe the approach taken by one institution to further individualize medicine by offering, executing and interpreting whole exome sequencing on a clinical basis through an enterprise-wide, standalone individualized medicine clinic. We present our experience designing and executing such an individualized medicine clinic, sharing lessons learned and describing early implementation outcomes.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalAmerican Journal of Medical Genetics, Part C: Seminars in Medical Genetics
Volume166
Issue number1
DOIs
StatePublished - 2014

Fingerprint

Precision Medicine
Medicine
Patient Care
Exome
Workflow
Evidence-Based Medicine
Genomics
Technology
Costs and Cost Analysis
Therapeutics

Keywords

  • Genomic medicine
  • Individualized medicine clinic
  • Personalized medicine
  • Whole exome sequencing

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Implementing individualized medicine into the medical practice. / Lazaridis, Konstantinos N; MCAllister, Tammy M.; Babovic-Vuksanovic, Dusica; Beck, Scott A.; Borad, Mitesh J; Bryce, Alan H; Chanan Khan, Asher A; Ferber, Matthew J.; Fonseca, Rafael; Johnson, Kiley J.; Klee, Eric W; Lindor, Noralane Morey; MCCormick, Jennifer B.; Mc Williams, Robert R; Parker, Alexander; Riegert-Johnson, Douglas L.; Rohrer Vitek, Carolyn R.; Schahl, Kimberly A.; Schultz, Cloann; Stewart, Alexander Keith; Then, George C.; Wieben, Eric D; Farrugia, Gianrico.

In: American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, Vol. 166, No. 1, 2014, p. 15-23.

Research output: Contribution to journalArticle

@article{22fb410e7cba41feb0a9229e24fe1645,
title = "Implementing individualized medicine into the medical practice",
abstract = "There is increasing recognition that genomic medicine as part of individualized medicine has a defined role in patient care. Rapid advances in technology and decreasing cost combine to bring genomic medicine closer to the clinical practice. There is also growing evidence that genomic-based medicine can advance patient outcomes, tailor therapy and decrease side effects. However the challenges to integrate genomics into the workflow involved in patient care remain vast, stalling assimilation of genomic medicine into mainstream medical practice. In this review we describe the approach taken by one institution to further individualize medicine by offering, executing and interpreting whole exome sequencing on a clinical basis through an enterprise-wide, standalone individualized medicine clinic. We present our experience designing and executing such an individualized medicine clinic, sharing lessons learned and describing early implementation outcomes.",
keywords = "Genomic medicine, Individualized medicine clinic, Personalized medicine, Whole exome sequencing",
author = "Lazaridis, {Konstantinos N} and MCAllister, {Tammy M.} and Dusica Babovic-Vuksanovic and Beck, {Scott A.} and Borad, {Mitesh J} and Bryce, {Alan H} and {Chanan Khan}, {Asher A} and Ferber, {Matthew J.} and Rafael Fonseca and Johnson, {Kiley J.} and Klee, {Eric W} and Lindor, {Noralane Morey} and MCCormick, {Jennifer B.} and {Mc Williams}, {Robert R} and Alexander Parker and Riegert-Johnson, {Douglas L.} and {Rohrer Vitek}, {Carolyn R.} and Schahl, {Kimberly A.} and Cloann Schultz and Stewart, {Alexander Keith} and Then, {George C.} and Wieben, {Eric D} and Gianrico Farrugia",
year = "2014",
doi = "10.1002/ajmg.c.31387",
language = "English (US)",
volume = "166",
pages = "15--23",
journal = "American Journal of Medical Genetics, Part A",
issn = "0148-7299",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Implementing individualized medicine into the medical practice

AU - Lazaridis, Konstantinos N

AU - MCAllister, Tammy M.

AU - Babovic-Vuksanovic, Dusica

AU - Beck, Scott A.

AU - Borad, Mitesh J

AU - Bryce, Alan H

AU - Chanan Khan, Asher A

AU - Ferber, Matthew J.

AU - Fonseca, Rafael

AU - Johnson, Kiley J.

AU - Klee, Eric W

AU - Lindor, Noralane Morey

AU - MCCormick, Jennifer B.

AU - Mc Williams, Robert R

AU - Parker, Alexander

AU - Riegert-Johnson, Douglas L.

AU - Rohrer Vitek, Carolyn R.

AU - Schahl, Kimberly A.

AU - Schultz, Cloann

AU - Stewart, Alexander Keith

AU - Then, George C.

AU - Wieben, Eric D

AU - Farrugia, Gianrico

PY - 2014

Y1 - 2014

N2 - There is increasing recognition that genomic medicine as part of individualized medicine has a defined role in patient care. Rapid advances in technology and decreasing cost combine to bring genomic medicine closer to the clinical practice. There is also growing evidence that genomic-based medicine can advance patient outcomes, tailor therapy and decrease side effects. However the challenges to integrate genomics into the workflow involved in patient care remain vast, stalling assimilation of genomic medicine into mainstream medical practice. In this review we describe the approach taken by one institution to further individualize medicine by offering, executing and interpreting whole exome sequencing on a clinical basis through an enterprise-wide, standalone individualized medicine clinic. We present our experience designing and executing such an individualized medicine clinic, sharing lessons learned and describing early implementation outcomes.

AB - There is increasing recognition that genomic medicine as part of individualized medicine has a defined role in patient care. Rapid advances in technology and decreasing cost combine to bring genomic medicine closer to the clinical practice. There is also growing evidence that genomic-based medicine can advance patient outcomes, tailor therapy and decrease side effects. However the challenges to integrate genomics into the workflow involved in patient care remain vast, stalling assimilation of genomic medicine into mainstream medical practice. In this review we describe the approach taken by one institution to further individualize medicine by offering, executing and interpreting whole exome sequencing on a clinical basis through an enterprise-wide, standalone individualized medicine clinic. We present our experience designing and executing such an individualized medicine clinic, sharing lessons learned and describing early implementation outcomes.

KW - Genomic medicine

KW - Individualized medicine clinic

KW - Personalized medicine

KW - Whole exome sequencing

UR - http://www.scopus.com/inward/record.url?scp=84896317365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896317365&partnerID=8YFLogxK

U2 - 10.1002/ajmg.c.31387

DO - 10.1002/ajmg.c.31387

M3 - Article

C2 - 24616301

AN - SCOPUS:84896317365

VL - 166

SP - 15

EP - 23

JO - American Journal of Medical Genetics, Part A

JF - American Journal of Medical Genetics, Part A

SN - 0148-7299

IS - 1

ER -