Impairments in immune cell function in B cell chronic lymphocytic leukemia

M. M. Bartik, D. Welker, Neil Elliot Kay

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

B cell chronic lymphocytic leukemia (B-CLL) is a common clonal B cell leukemia that is often accompanied by a multitude of immune abnormalities. Each immune defect may be linked to several of the common complications affecting B-CLL patients. Furthermore, the combined abnormalities constitute a significant immunodeficiency for each patient. Importantly, some of the immune dysfunctions are potentially very relevant to the in vivo survival status of the leukemic B cell. The elucidation of these abnormalities in the circulating non-malignant immune cells of B-CLL patients has generated important insights into the biology of the disease. This discussion reviews the immune abnormalities of the clonal malignant B cells, the polyclonal B cells, and the immunoregulatory T cells and natural killer cells in B-CLL. In addition, we indicate the potential for immunotherapeutic protocols as innovations in treating this disease.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalSeminars in Oncology
Volume25
Issue number1
StatePublished - 1998
Externally publishedYes

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B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
B-Cell Leukemia
Natural Killer Cells
T-Lymphocytes
Survival

ASJC Scopus subject areas

  • Oncology

Cite this

Impairments in immune cell function in B cell chronic lymphocytic leukemia. / Bartik, M. M.; Welker, D.; Kay, Neil Elliot.

In: Seminars in Oncology, Vol. 25, No. 1, 1998, p. 27-33.

Research output: Contribution to journalArticle

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