Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea

Masahiko Kato, Philip Roberts-Thomson, Bradley G. Phillips, William G. Haynes, Mikolaj Winnicki, Valentina Accurso, Virend Somers

Research output: Contribution to journalArticle

565 Citations (Scopus)

Abstract

Background - Patients with obstructive sleep apnea (OSA) experience repetitive episodic hypoxemia with consequent sympathetic activation and marked blood pressure surges, each of which may impair endothelial function. We tested the hypothesis that patients with OSA have impaired endothelium-dependent vasodilation, even in the absence of overt cardiovascular disease. Methods and Results - We studied 8 patients with OSA (age 44±4 years) and 9 obese control subjects (age 48±3 years). Patients with OSA were newly diagnosed, never treated for OSA, on no medications, and free of any other known diseases. All obese control subjects underwent complete overnight polysomnographic studies to exclude occult OSA. Resistance-vessel function was tested by use of forearm blood flow responses to intra-arterial infusions of acetylcholine (a vasodilator that stimulates endothelial release of nitric oxide), sodium nitroprusside (an exogenous nitric oxide donor), and verapamil (a calcium channel blocker). Conduit-vessel function was also evaluated by ultrasonography. Brachial artery diameter was measured under baseline conditions, during reactive hyperemia (with flow increase causing endothelium-dependent dilatation), and after sublingual administration of nitroglycerin (an endothelium-independent vasodilator). Patients with OSA had a blunted vasodilation in response to acetylcholine (P<0.007), but responses to sodium nitroprusside and verapamil were not significantly different from those of control subjects. No significant difference in conduit-vessel dilation was evident between OSA patients and obese control subjects. Conclusions - Patients with OSA have an impairment of resistance-vessel endothelium-dependent vasodilation. This may be implicated in the pathogenesis of hypertension and heart failure in this condition.

Original languageEnglish (US)
Pages (from-to)2607-2610
Number of pages4
JournalCirculation
Volume102
Issue number21
StatePublished - Nov 21 2000

Fingerprint

Obstructive Sleep Apnea
Vasodilation
Endothelium
Nitroprusside
Verapamil
Vasodilator Agents
Acetylcholine
Dilatation
Sublingual Administration
Intra Arterial Infusions
Brachial Artery
Nitric Oxide Donors
Hyperemia
Nitroglycerin
Calcium Channel Blockers
Forearm
Ultrasonography
Nitric Oxide
Cardiovascular Diseases
Heart Failure

Keywords

  • Endothelium
  • Obesity
  • Sleep

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Kato, M., Roberts-Thomson, P., Phillips, B. G., Haynes, W. G., Winnicki, M., Accurso, V., & Somers, V. (2000). Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation, 102(21), 2607-2610.

Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. / Kato, Masahiko; Roberts-Thomson, Philip; Phillips, Bradley G.; Haynes, William G.; Winnicki, Mikolaj; Accurso, Valentina; Somers, Virend.

In: Circulation, Vol. 102, No. 21, 21.11.2000, p. 2607-2610.

Research output: Contribution to journalArticle

Kato, M, Roberts-Thomson, P, Phillips, BG, Haynes, WG, Winnicki, M, Accurso, V & Somers, V 2000, 'Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea', Circulation, vol. 102, no. 21, pp. 2607-2610.
Kato M, Roberts-Thomson P, Phillips BG, Haynes WG, Winnicki M, Accurso V et al. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation. 2000 Nov 21;102(21):2607-2610.
Kato, Masahiko ; Roberts-Thomson, Philip ; Phillips, Bradley G. ; Haynes, William G. ; Winnicki, Mikolaj ; Accurso, Valentina ; Somers, Virend. / Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. In: Circulation. 2000 ; Vol. 102, No. 21. pp. 2607-2610.
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