Impaired myocardial autophagy linked to energy metabolism disorders

Zi Lun Li, Lilach O. Lerman

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Autophagy represents an evolutionarily conserved catabolic mechanism that promotes cell survival by releasing energy substrates via degradation of cellular constituents and by eliminating defective organelles under conditions of stress, such as starvation and hypoxia. The link between enhanced autophagy and nutrient deprivation has been well established. For example, chronic myocardial ischemia, a condition of insufficient oxygen and nutrition, activates autophagy to degrade and recycle damaged cellular structures, thereby ameliorating cardiomyocyte injury.

Original languageEnglish (US)
Pages (from-to)992-994
Number of pages3
JournalAutophagy
Volume8
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • Apoptosis
  • Autophagy
  • Energy metabolism
  • MTOR
  • Metabolic syndrome
  • Mitochondrial biogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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